Role of Hypothermia in Endovascular Stroke Thrombectomy

Inclusion criteria

• Aged ≥ 18 years or more;
• acute ischemic stroke within 24 hours from onset to randomization;
• NIHSS ≥6 points before randomization;
• Internal carotid artery, or the middle cerebral artery M1 or M2 occlusion confirmed by CTA/MRA/DSA;
• Baseline ASPECTS score ≥ 3 and ≤8, or cerebral infarction core volume < 100ml;
• The patient decides to undergo endovascular therapy;
• The patient or patient's representative signs a written informed consent form.

Exclusion criteria

• CT or MR evidence of hemorrhage;
• Currently pregnant or lactating (women patients);
• Allergy to radiographic contrast agents, or nitinol devices;
• Arterial tortuosity and/or other arterial disease that would prevent the device from reaching the target vessel;
• Multiple vessel occlusion (e.g., bilateral anterior circulation, or occlusion of both anterior and posterior circulation);
• Preexisting neurological or psychiatric disease that would confound the neurological functional evaluations;
• Previous bleeding disorders, severe heart, liver or kidney disease, or sepsis;
• Brain tumors with mass effect (except meningiomas) that are radiographically pleasant;
• Intracranial aneurysm, arteriovenous malformation;
• Any terminal illness with life expectancy less than 6 months;
• Participating in other clinical trials.