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NCT Number: NCT07470931

Role of High-Frequency Oscillations on Scalp EEG in Identifying Epileptogenic Activity in Patients With Epilepsy and Healthy Controls

This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. A signal-processing algorithm was developed to identify HFO activity in scalp EEG recordings, with particular focus on ripple (80-250 Hz) and fast ripple (250-500 Hz) frequency bands. Scalp EEG recordings obtained from patients with epilepsy and healthy controls are analyzed after preprocessing and filtering steps. The main outcome is the mean residence time of HFO-related activity above a predefined threshold in the ripple and fast ripple bands. The study investigates whether this noninvasive EEG-based approach may provide a useful biomarker for epilepsy diagnosis.

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Key information

Conditions

Epilepsies Brain Diseases Central Nervous System Diseases Epilepsy Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Saglik Bilimleri University Izmir Faculty of Medicine Department of Neurology

Izmir, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Inclusion Criteria for Epilepsy Group

Adults diagnosed with epilepsy

Availability of routine awake scalp EEG recording suitable for analysis

EEG recorded with the study protocol and technical specifications

Inclusion criteria

for Control Group

Adults without epilepsy

Referred for EEG evaluation in the context of syncope differential diagnosis

Scalp EEG recording suitable for analysis

Exclusion criteria

  • EEG recordings with inadequate technical quality or excessive artifact burden preventing HFO analysis

Individuals not meeting study group definitions

Treatment and study plan

Primary outcomes

  1. Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG

    Time frame: At the time of EEG assessment / baseline

    The mean duration for which the ripple-band signal envelope remains above the predefined threshold, compared between epilepsy and control groups.

Sponsors and collaborators

Lead sponsor

Saglik Bilimleri Universitesi

Other

Registry information

Official study title

Evaluation of High-Frequency Oscillations Detected by a Novel Signal Analysis Algorithm on Scalp Electroencephalography for Differentiating Patients With Epilepsy From Healthy Controls

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Mar 13, 2026
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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