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Completed

NCT Number: NCT01315093

Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation

The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

25 year–43 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

3rd Department of Obstetrics & Gynecology

Athens, Chaidari, 12642, Greece

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • poor responders (age>40, abnormal ovarian test, </=4 oocytes in previous cycle with conventional stimulation)
  • infertility, indication for IVF
  • no contraindications for heparin

Treatment and study plan

Heparin, Low-Molecular-Weight

Drug

Heparin from start till hcg test

no heparin

Drug

Primary outcomes

  1. no of oocytes retrieved

    Time frame: egg recovery, 2 years

    >2 between groups

Secondary outcomes

  1. clinical pregnancy rate

    Time frame: 2 years

    Presence of fetal heart at transvaginal ultrasound at 6+2 gestational weeks

  2. live birth rate

    Time frame: 2 years

    >20 weeks of gestation

  3. cancellation rate

    Time frame: before ET, 2 years

  4. miscarriage rate

    Time frame: 2 years

    pregnancy loss <20 weeks

Sponsors and collaborators

Lead sponsor

National and Kapodistrian University of Athens

Other

Registry information

Important dates

Study start
2010
Primary completion
2016
Study completion
2016
First posted
Mar 15, 2011
Registry last updated
May 1, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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