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Completed

NCT Number: NCT01692444

Role of Fibrocytes in the Bronchial Remodelling of Chronic Obstructive Pulmonary Disease

Airway remodelling is an abnormal tissue repair following bronchial inflammation, which contributes to none reversible pathological features, such as bronchial and peri-bronchial fibrosis. It also influences the prognosis of Chronic Obstructive Pulmonary Disease (COPD) and its mechanisms remain largely unknown. The role of fibrocytes has been demonstrated in the pathophysiology of asthma, lung fibrosis or pulmonary hypertension. However, the recruitment of blood fibrocytes and their involvement in COPD airway remodelling remain unknown.

The main objective of the study is to analyse the distribution and quantify the number of the peri-bronchial and blood circulating fibrocytes in patients with different stages of COPD compared to control subjects.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Fibrosis Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University hospital of Bordeaux, Hôpital du Haut Lévêque

Pessac, 33604, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or female aged more than 40 yr
  • Patient needed a thoracic surgery such as lobectomy for cancer or lung transplantation or lung reduction volume surgery.
  • COPD group: diagnostic of COPD and differentiation of the stage from 1 to 4 according to the GOLD guidelines.
  • Control group: subjects with normal lung function testing and no chronic symptoms (cough or expectoration). Subjects will be separated in 2 groups according to smoking history (Never smokers, smokers (former or current) and paired to patients according to age and sex.
  • with a written informed consent

Exclusion criteria

  • Subject without any social security or health insurance
  • Asthma, lung fibrosis or idiopathic pulmonary hypertension
  • Chronic viral infections (hepatitis, HIV)
  • Pregnant woman or breastfeeding
  • Subject included for cancer surgery with a Pn0 diagnosis not confirmed after the intervention.

Treatment and study plan

analyse the distribution and quantify the number of the peri-bronchial and blood circulating fibrocytes in patients

Biological

analyse the distribution and quantify the number of the peri-bronchial and blood circulating fibrocytes in patients

Primary outcomes

  1. Increased number of peri-bronchial and blood circulating fibrocytes gradually in each stages of COPD and compared to control subjects.

    Time frame: Lung tissues and blood samples will be collected at inclusion visit during surgery (Day 0)

Secondary outcomes

  1. Characterization of fibrocytes: expression of chemokines receptors, Toll Like Receptors, HLA class II

    Time frame: Lung tissues and blood samples will be collected at inclusion visit during surgery (Day 0)

  2. Correlation between lung attenuation and the number of fibrocytes

    Time frame: Assessed one year after inclusion visit (i.e. surgery date =Day 0)

  3. Correlation between plethysmography and the number of fibrocytes.

    Time frame: Assessed one year after inclusion visit (i.e. surgery date = Day 0)

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Acronym: FIBROCHIR

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Sep 25, 2012
Registry last updated
Jun 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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