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Completed

NCT Number: NCT03004573

Role of Deep Brain Stimulation on Social Cognition in Parkinsonian Patients

Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life. Social cognition is a complex system relying on emotion recognition (neurons mirror system, NMS), the theory of mind (with its two parts: emotional and cognitive), but also on the social and cultural environment and the personal history. The first step in this model is represented by the NMS, which seems to be altered in PD patients for both positive and negative emotions as shown in our preliminary study. The investigator purpose is to investigate the role of the treatment (levodopa and deep brain stimulation) on the functioning of the NMS.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Service de Neurologie C Hôpital " Pierre Wertheimer "

Bron, 69500, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Parkinson's disease with motor fluctuations and dyskinesias receiving deep-brain stimulation
  • Social insurance

Exclusion criteria

  • No affiliation to the social insurance
  • Patients under guardianship

Treatment and study plan

Neuropsychological detailed tests with focus on social cognition

Other

MATTIS, MOCA, BREF, Light points test, PDQ39

Primary outcomes

  1. variation of the emotional recognition score (point lights test) before deep brain surgery

    Time frame: Baseline

  2. variation of the emotional recognition score (point lights test) after deep brain surgery

    Time frame: 1 year

Secondary outcomes

  1. PDQ39 score (Parkinson's Disease Questionnaire)

    Time frame: 1 year

    Quality of Life

  2. MATTIS (dementia rating scale) score

    Time frame: 1 year

    Global cognition. The Clinical Dementia Rating or CDR is a numeric scale used to quantify the severity of symptoms of dementia

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Official study title

Functioning of the Mirror Neurons System in Parkinson's Disease and Its Impact on the Social Cognition

Important dates

Study start
2017
Primary completion
2019
Study completion
2019
First posted
Dec 29, 2016
Registry last updated
Feb 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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