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NCT Number: NCT07247435

Role of CT in Tetralogy of Fallot Diagnosis

To evaluate the role of MSCT in diagnosis and surgical planning in tetralogy of Fallot cases.

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Key information

Conditions

Age range

Up to 12 year

Sex eligibility

All sexes

Study type

Observational

About this study

Role of Computed tomography (CT) : CT has become an indispensable imaging modality in the comprehensive evaluation and management of Tetralogy of Fallot (ToF). While echocardiography remains the initial diagnostic tool, CT offers unparalleled spatial resolution and the ability to generate high-quality, three-dimensional reconstructions of both intracardiac and extracardiac anatomy. This is particularly valuable for identifying associated anomalies such as major aortopulmonary collateral arteries (MAPCAs), anomalous coronary artery origins, and variations in pulmonary artery branching patterns that can significantly influence surgical decision-making. Preoperatively, CT enables precise assessment of the severity and extent of right ventricular outflow tract obstruction, ventricular septal defect morphology, and the relationship of the overriding aorta to the interventricular septum.

Overall, CT complements other imaging modalities by providing a fast, accurate, and comprehensive anatomical roadmap that guides surgical planning, informs long-term follow-up, and aids in the early detection of complications. Its role is particularly pronounced in complex and syndromic cases of ToF, where anatomical variations are more common and precise preoperative mapping is critical for successful outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged 1 day up to 12 years Confirmed diagnosis of tetralogy of Fallot. Patients with tetralogy of Fallot as apart from genetic syndrome.

Exclusion criteria

  • Patients with other isolated congenital heart anomalies Previously operated cases of tetralogy of Fallot.

Treatment and study plan

computed tomography

Device

Radiological device

Primary outcomes

  1. Anatomical anomalies identification

    Time frame: 3 years

    Identification cardiac and extra-cardiac anatomical anomalies

Study contacts

Contact information is provided by the study sponsor or research team.

Benyamin Gaballah

CONTACT

[email protected]

01025303267

Hassan Megaly, Professor

CONTACT

01006209584

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Role of Computed Tomography in Diagnosis of Syndromic and Non Syndromic Tetralogy of Fallot

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Nov 25, 2025
Registry last updated
Nov 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.