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NCT Number: NCT06841471

Role of Corneal Nerves in Dry Eye Disease

This study aims to determine whether corneal nerve function and morphology are affected by tear film instability and ocular surface homeostasis loss. Additionally, it seeks to investigate whether these factors vary based on the severity of dry eye symptoms.

Recruiting

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Key information

Conditions

Dry Eye Disease (DED) Corneal Nerve Dry Eye Dry Eye Sensation Dry Eye Syndromes Eye Diseases Lacrimal Apparatus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Optometrym FHNW

Olten, 4600, Switzerland

Location status: Recruiting

Location contact

Daniela S Nosch, BSc MSc PhD

CONTACT

[email protected]

41629572603

Emanuele Käser, BSc MSc

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Group with DED: Diagnosis of DED based on the TFOS DEWS II report
  • Group without DED: No diagnosis of DED

Exclusion criteria

  • Exclusion criteria:
  • Systemic disease that may affect ocular health and innervation
  • injury or history of operations on the anterior or posterior segment of the eye, which can affect the corneal structure and physiology
  • regular application of systemic or ocular medication known to affect the tear film except from DED medications
  • eye drops or makeup on the day of measurement.

Remarks:

Contact lens wearers are asked not to wear contact lenses for 1 week before the first appointment.

Participant with DED medications will be asked to use only conservative-free eye drops on the days of examination

Treatment and study plan

Primary outcomes

  1. Differences of corneal nerve function and morphology in relation with DED signs

    Time frame: within one week

    Correlation coefficient between corneal sensitivity and corneal nerve morphology, and variables related to tear film stability and corneal surface homeostasis.

Secondary outcomes

  1. Differences of corneal nerve function and morphology in relation with DED symptoms

    Time frame: within one week

    Correlation coefficient between corneal sensitivity, corneal nerve morphology, and the severity of dry eye symptoms.

Study contacts

Contact information is provided by the study sponsor or research team.

Daniela S Nosch, BSc MSc PhD

CONTACT

[email protected]

41629572603

Emanuele Käser, BSc MSc

CONTACT

[email protected]

41629572302

Sponsors and collaborators

Lead sponsor

Daniela Nosch

Other

Registry information

Official study title

Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Feb 24, 2025
Registry last updated
Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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