Role of B2 Adrenergic Receptors in Labor Pain

The study aims to understand why labor is more painful for some women compared to others. The study will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.

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Key information

Conditions

Pain Labor Pain Labour Pain Neurologic Manifestations Pain Threshold Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Columbia University

New York, 10032, United States

About this study

Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. The study will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. The investigators will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

nulliparous women
Third trimester of pregnancy on enrollment

Exclusion criteria

Chronic Pain
Pain medication utilization
Large for gestational age baby
Small for gestational age baby
Systemic illness

Sponsors and collaborators

Lead sponsor

Columbia University

Other

Registry information

Important dates

Study start: 2006
Primary completion: 2009
Study completion: 2009
First posted: Oct 9, 2006
Registry last updated: Jul 18, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed