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Completed

NCT Number: NCT01024543

Role of Angiotensin II in Insulin-induced Microvascular Activity

In this study we hypothesize infusion of Angiotensin II improves the insulin-induced microvascular dilatation and therefore insulin-mediated glucose uptake. Objectives: Does infusion of Angiotensin II increase insulin-mediated glucose uptake via enhanced insulin-mediated microvascular function in healthy subjects?

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Key information

Conditions

Insulin Sensitivity Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Microcirculation Nutritional and Metabolic Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Maastricht University Medical Centre

Maastricht, P.o. Box 5800, Netherlands, 6202 AZ, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

1.18-60 years 2.Caucasian 3.Blood pressure <140/90 mmHg.

Exclusion criteria

  • Obesity (BMI>27kg/m2)
  • Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, heart failure)
  • Impaired glucose tolerance or diabetes mellitus according to the criteria of the ADA
  • Smoking
  • Alcohol use >4U/day
  • Use of medication (antihypertensive drugs, lipid lowering drugs, corticosteroids, NNSAIDs)
  • Pregnancy
  • Wearing contact lenses

Treatment and study plan

Angiotensin II

Drug

Angiotensin II

Phenylephrine

Drug

Phenylephrine

Placebo

Drug

Primary outcomes

  1. functional recruitment of capillaries in the skin

    Time frame: January 2009

Secondary outcomes

  1. perfused capillary density in the nailfold

    Time frame: January 2009

  2. Endothelium- (in)dependent vasodilatation of finger skin microcirculation

    Time frame: January 2006

  3. Insulin sensitivity

    Time frame: January 2009

Sponsors and collaborators

Lead sponsor

Maastricht University Medical Center

Other

Registry information

Important dates

Study start
2006
Primary completion
2009
Study completion
2009
First posted
Dec 2, 2009
Registry last updated
Dec 2, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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