Role of Amlodipine in Reduction of CIN

The aim is to assess the benefit of low dose oral amlodipine in renal protection from contrast induced nephropathy in diabetic patients in intensive care unit

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Key information

Conditions

Contrast-induced Nephropathy

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult patients of both sexes (18:70) diabetic patients with serum creatinine below 1.2 hemodynamically stable patients ASA physical status 2,3

Exclusion criteria

patient refusal patients of chronic kidney diseases NPO patients serum creatinine above 1.2 Hypertensive patients

Treatment and study plan

Calcium channel blocker

Drug

amlodipine group will receive low dose oral amlodipine ( 5 mg ) before iv contrast and every 12 hour for 48 hour

Other names: amlodipine ( 5mg)

hydration

Other

before the procedure patients will recieve iv bolus of 250 ml saline followed by continous infusion of 100 ml/h of normal saline

Primary outcomes

measuring serum creatinine level

Time frame: baseline

measuring serum creatinine level before the procedure and every day for 48 hours after

Study contacts

Contact information is provided by the study sponsor or research team.

Andrew Shehata, Master

CONTACT

[email protected]

0201067820073

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

The Effect of Low Dose Oral Amlodipine in Renal Protection From Contrast Induced Nephropathy in Diabetic Patients in Intensive Care Unit

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Dec 18, 2025
Registry last updated: Dec 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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