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Completed

NCT Number: NCT02711917

Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.

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Key information

Conditions

Neuromuscular Monitoring

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

2 age group of patients was selected, 40-60 years and above 60 years. Maintenance of anesthesia was carried out using different concentration of Sevoflurane, ie MAC 0.5, 0.75 and 1.0. Bis value was kept between 40-60 and the dose of propofol required was recorded. Rocuronium infusion given in a close loop infusion system for different group was tabulated. The results was then analysed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI < 30
  • elective Gynaecological/abdominal/urological surgery
  • Operation time < 3hrs
  • ASA I/II
  • Intubated patients

Exclusion criteria

  • Coronary artery disease, cardiac, lung, hepatic and renal insufficiency
  • Severe uncontrolled HBP
  • Obesity (BMI >30)
  • Neuromuscular and metabolic diseases
  • Receiving medication known to influence neuromuscular transmission
  • Pregnancy
  • Psychiatric disorders
  • Allergy history to any of the drugs that will be used

Treatment and study plan

MAC 0.5

Drug

0.5 MAC Sevoflurane

MAC 0.75

Drug

0.75 MAC Sevoflurane

MAC 1.0

Drug

1.0 MAC Sevoflurane

Propofol

Drug

Propofol consumption

Etomidate

Drug

Etomidate consumption

Rocuronium

Drug

Consumption of Rocuronium

Primary outcomes

  1. consumption of propofol

    Time frame: Intraoperative

    Propofol, Etomidate, Rocuronium consumption under specific concentration of sevoflurane keeping BIS between 40-60

Secondary outcomes

  1. Recovery Index

    Time frame: Intraoperative

    T25%-T75%

  2. Onset time

    Time frame: Intraoperative

    Time from starting infusion of Rocuronium at induction till T<10%

  3. Sevoflurane time

    Time frame: Intraoperative

    Time from starting sevoflurane till end tidal concentration is reached

Sponsors and collaborators

Lead sponsor

Tianjin Medical University General Hospital

Other

Registry information

Official study title

Consumption of Rocuronium Under Etomidate-based Versus Propofol-based Maintenance of General Anesthesia Under Different Concentration of Sevoflurane- BIS Guided Clinical Trial in a Closed Loop Infusion System

Important dates

Study start
2015
Primary completion
2015
Study completion
2016
First posted
Mar 17, 2016
Registry last updated
Mar 17, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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