RNA Sequencing of Solid and Cystic Lesions of the Pancreas

The nature of cysts and solid masses in the pancreas can be difficult to diagnose. They may be benign, precancerous, or cancer. Current tests such as cytology (looking under a microscope) and tumor markers do not always give us the answer. The investigators are looking for genetic markers on biopsy specimens from the pancreas that will give us a better test for diagnosis. This study is only for diagnosing these lesions. The investigators are not treating any patients.

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Key information

Conditions

Pancreas Cyst Cysts Digestive System Diseases Neoplasms Pancreas Mass Pancreatic Cyst Pancreatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Oregon Health and Science University, Portland, Oregon, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

greater than 18 years old,
not pregnant,
referred for endoscopic ultrasound,
have a cyst or mass of the pancreas needing diagnosis.

Exclusion criteria

pregnant,
less than age 18,
no mass or cyst found.

Treatment and study plan

pancreas biopsy

Procedure

patients who are already having a pancreas biopsy will be invited to enroll. After obtaining enough tissue for usual medical care, we will divert some tissue for the study.

Other names: RNA sequencing of pancreas tissue

Primary outcomes

Gene classifier that will classify lesions as benign or malignant with 95% certainty

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Oregon Health and Science University

Other

Collaborators

Providence Health & Services

Registry information

Important dates

Study start: 2012
Primary completion: 2017
Study completion: 2019
First posted: Mar 8, 2013
Registry last updated: Jan 10, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed