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Completed

NCT Number: NCT07462273

RISS Block for Enhanced Recovery After Video-Assisted Thoracoscopic Surgery

This prospective randomized controlled trial evaluates the efficacy and safety of ultrasound-guided rhomboid intercostal and subserratus plane (RISS) block for postoperative analgesia in patients undergoing video-assisted thoracoscopic surgery (VATS).

Postoperative pain after VATS can impair respiratory function, delay mobilization, and increase opioid consumption. Although several regional anesthesia techniques are available, the optimal analgesic strategy remains under investigation. The RISS block is a novel fascial plane block that may provide effective thoracic analgesia while minimizing opioid-related adverse effects.

A total of 90 adult patients scheduled for elective VATS will be randomly assigned to receive either ultrasound-guided RISS block combined with general anesthesia or general anesthesia alone. The primary outcomes include postoperative 24-hour benefit of analgesia score (BCS) and patient-controlled intravenous analgesia (PCIA) pressing frequency. Secondary outcomes include postoperative pain scores, opioid consumption, and adverse events.

This study aims to determine whether RISS block improves postoperative recovery and reduces opioid requirements after VATS.

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Key information

Conditions

Postoperative Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms Thoracic Surgery Video-Assisted Thoracic Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The Affiliated Hospital of Ningbo University

Ningbo, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults aged 18 years or older

ASA physical status I-II

Scheduled for elective video-assisted thoracoscopic surgery (VATS)

Provided written informed consent

Exclusion criteria

History of shock or coma

Coagulopathy

Local infection at the puncture site

Pre-existing nerve injury on the side intended for block

Chronic analgesic use

Psychiatric disorders

Prior thoracic or breast surgery

Allergy to local or general anaesthetic agents

Body mass index (BMI) ≥35 kg/m²

Inability to operate a patient-controlled analgesia (PCA) device

Treatment and study plan

Rhomboid Intercostal and Subserratus Plane Block with local anesthetic

Procedure

Ultrasound-guided dual-plane RISS block performed after induction of general anesthesia. A total of 40 mL of 0.375% ropivacaine (150 mg) was administered across the rhomboid-intercostal plane and low subserratus plane.

Intercostal Nerve Block

Procedure

Ultrasound-guided intercostal nerve block performed at surgical port levels (T4-T7) using 0.375% ropivacaine with total dose ≤75 mg.

Primary outcomes

  1. 24-hour cumulative number of effective PCA presses

    Time frame: Within 24 hours postoperatively

  2. Bruggrmann Comfort Scale (BCS) score at 24 hours

    Time frame: 24 hours after surgery

Sponsors and collaborators

Lead sponsor

Ningbo University

Other

Registry information

Official study title

A Prospective Randomized Controlled Trial Evaluating the Efficacy and Safety of Ultrasound-Guided Rhomboid Intercostal and Subserratus Plane Block for Enhanced Recovery After Video-Assisted Thoracoscopic Surgery

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 10, 2026
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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