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NCT Number: NCT07316452

Risk Prediction of Disease Progression in Early-Onset Coronary Atherosclerosis

This study is part of a nationwide research project in China that aims to better understand how coronary artery disease develops and progresses in young adults. The study will enroll approximately 10,000 participants aged 45 years or younger who undergo coronary CT scans at multiple hospitals across China.

Information collected at enrollment includes basic health information, cardiovascular risk factors, blood test results, medication use, lifestyle habits, and, for some participants, genetic data. Participants will undergo follow-up coronary CT scans after several years to evaluate changes in coronary artery plaque and disease progression.

By analyzing these clinical and imaging data, the study aims to identify factors associated with disease progression and to develop prediction models that may help estimate an individual's future risk of coronary plaque progression and cardiovascular events. The results of this study may contribute to improved risk assessment and early prevention strategies for coronary artery disease in young populations.

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Key information

Conditions

Coronary Disease Cardiovascular Diseases Heart Diseases Myocardial Ischemia Vascular Diseases Young Adult

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 45 years at the time of enrollment.
  • Presence of symptoms suggestive of coronary artery disease and completion of coronary computed tomography (CT) examination.
  • Ability and willingness to provide written informed consent and to participate in follow-up assessments.

Exclusion criteria

  • Inability or unwillingness to complete follow-up assessments.
  • Inability to provide written informed consent.
  • History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting.
  • Poor-quality coronary computed tomography images that are inadequate for reliable plaque assessment.
  • Presence of severe systemic disease with limited life expectancy that may interfere with study follow-up.
  • Pregnant or breastfeeding women.
  • Participation in another clinical study that may interfere with the outcomes of this study.

Treatment and study plan

Primary outcomes

  1. Progression of Coronary Plaque on Computed Tomography

    Time frame: From baseline to follow-up coronary CT, up to 3 years

    Progression of coronary atherosclerotic plaque assessed by comparing baseline and follow-up coronary computed tomography scans.

Study contacts

Contact information is provided by the study sponsor or research team.

Zhihui Hou, MD, PhD

CONTACT

[email protected]

+86 15011451210

Sponsors and collaborators

Lead sponsor

Fu Wai Hospital, Beijing, China

Other

Registry information

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Jan 5, 2026
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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