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OpenTrials
Completed

NCT Number: NCT05385874

Risk Prediction and Its Intelligent Assessment for Cognitive Impairment Among Community-dwelling Older Adults

Cognitive impairment is one of the core early signs of dementia, and it is also a key stage for community-based dementia prevention. Accurate and convenient prediction of cognitive impairment can help the community to identify and manage the high-risk population of dementia. Previous studies had developed several dementia predicting models, but such models may be not suitable for cognitive impairment prediction. Based on the national representative follow-up data of Chinese Longitudinal Healthy Longevity Survey (CLHLS), this project aims to develop and validate a brief cognitive impairment prediction algorithm among the community-dwelling elderly, using machine learning methods (such as Logistic regression, Naïve Bayes model, Extreme Gradient Boosting Tree and so on). Finally, based on the constructed model, an easy-to-use online intelligent assessment tool for predicting cognitive impairment risk will be developed. The general practitioners, social workers and the elderly would be invited to use the tool and we will revise the tool according to their suggestions and comments. This project is expected to provide scientific basis and technical support for community-based dementia prevention, and will also be useful for the elderly to easily understand their cognitive health.

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Key information

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking University Six Hospital

Beijing, 100191, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 65 or over at baseline;
  • With normal cognitive function at baseline (score ≥ 18 on the Chinese version of Mini-Mental State Examination, MMSE);
  • Completed MMSE assessment three years later;
  • Provided informed consent voluntarily.

Exclusion criteria

  • Aged <65;
  • had a history of dementia or MMSE score < 18 at baseline;
  • lost to follow-up or without cognitive function assessment three years later;
  • Refused to participate the survey.

Treatment and study plan

Primary outcomes

  1. AUC

    Time frame: an average of 3 years after baseline assessement

    the AUC of the prediciton model based on the test data

Secondary outcomes

  1. sensitivity

    Time frame: an average of 3 years after baseline assessement

    the sensitivity of the prediciton model based on the test data

  2. specificity

    Time frame: an average of 3 years after baseline assessement

    the specificity of the prediciton model based on the test data

  3. positive predictive value

    Time frame: an average of 3 years after baseline assessement

    the positive predictive value of the prediciton model based on the test data

  4. negative predictive value

    Time frame: an average of 3 years after baseline assessement

    the negative predictive value of the prediciton model based on the test data

Sponsors and collaborators

Lead sponsor

Peking University Sixth Hospital

Other

Registry information

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
May 23, 2022
Registry last updated
Apr 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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