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NCT Number: NCT06079424

Risk Markers of Arterial Aging. The Paris Prospective Study III-2

The main objectives of PPS3-2 are (i) to describe the dynamics of vascular aging and baroreflex sensitivity 12 to 16 years a part, (ii) to identify their determinants, and (iii) to quantify the subsequent risk of cardiovascular diseases.

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Key information

Conditions

Arterial Stiffness Cardiovascular Diseases

Age range

60 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre d'Investigation Précliniques

Paris, 75016, France

Location status: Recruiting

Location contact

Jean-Philippe Empana

CONTACT

[email protected]

Jean-Philippe Empana

PRINCIPAL_INVESTIGATOR

Nicolas Danchin

CONTACT

[email protected]

0153673535

About this study

Since May 2008, PPS3 is being following the CVD morbidity of 10157 healthy volunteers aged 50-75 years at baseline. In PPS3-2, we plan to re-invite survivors and volunteers of PPS3 to undergo a second physical examination. In particular, they will undergo a second high-precision carotid echotracking to measure vascular aging parameters and baroreflex sensitivity, permitting to study their respective dynamics. They will also underwent for the first time ultra fast echo of the radial artery to measure vascular aging parameters of the medium-sized arteries. According to fundings, blood samples will be taken and stored at -80°C in the whole population or in a subsample.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being enrolled in PPS3 and having signed an informed consent for PPS3-2

Exclusion criteria

  • Institutionalized participants
  • Participants under guardianship
  • Participants under judicial safeguard measure

Treatment and study plan

high-precision carotid echo-tracking

Other

evaluation of vascular aging parameters and baroreflex sensitivity

Primary outcomes

  1. carotid diameter

    Time frame: by 2027

    high precision carotid echo tracking diameter in mm

  2. intima media thickness

    Time frame: by 2027

    high precision echo tracking intima media thickness of the common carotid artery in mm

  3. carotid plaques

    Time frame: by 2027

    high precision carotid echo tracking carotid plaques

  4. wall cross sectional area

    Time frame: by 2027

    high precision carotid echo tracking carotid wall cross sectional area, mm2

  5. distensibility coefficient

    Time frame: by 2027

    high precision carotid echo tracking distensibility coefficient in 10-3/kPa

  6. elastic modulus

    Time frame: by 2027

    high precision carotid echo tracking Young's elastic modulus, 10-3*kPa

  7. pulse wave velocity

    Time frame: by 2027

    high precision carotid echotracking pulse wave velocity, m/s

  8. carotid wall stress

    Time frame: by 2027

    high precision carotid echotracking circumferential wall stress in kPa

  9. stiffness

    Time frame: by 2027

    high precision carotid echotracking Beta stiffness index

  10. pulse pressure

    Time frame: by 2027

    high precision carotid echotracking pulse pressure in mmHg

Secondary outcomes

  1. brachial artery diameter

    Time frame: by 2027

    ultra high frequency ultrasound radial artery diameter in mm

  2. thickness of the intima media of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery intima media thickness in mm

  3. arterial plaques

    Time frame: by 2027

    ultra high frequency ultrasound radial artery plaques

  4. wall cross sectional area of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery wall cross sectional area, mm2

  5. distensibility of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery distensibility coefficient in 10-3/kPa

  6. elastic modulus of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery Young's elastic modulus, 10-3*kPa

  7. pulse wave velocity of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery Pulse wave velocity, m/s

  8. stiffness index of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery Beta stiffness index

  9. wall stress of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery Circumferential wall stress, kPa

  10. pulse pressure of the radial artery

    Time frame: by 2027

    ultra high frequency ultrasound radial artery Pulse Pressure, mmHg

Study contacts

Contact information is provided by the study sponsor or research team.

Jean-Philippe Empana, MD, PhD

CONTACT

[email protected]

33153988020

Xavier Jouven, MD, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Risk Markers of Arterial Aging and Subsequent Risk of Cardiovascular Diseases and Beyond. The Paris Prospective Study III-2

Acronym: PPS3-2

Important dates

Study start
2025
Primary completion
2031
Study completion
2033
First posted
Oct 12, 2023
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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