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NCT Number: NCT06449547

Risk Factors of Anxiety and Depression in Patients With Herpes Zoster Neuralgia

The goal of this observational study is to explore risk factors of anxiety and depression in patients with herpes zoster neuralgia, and the changes of certain serum biomarkers and functional brain magnetic resonance images of these patients.

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Key information

Conditions

Herpes Zoster Anxiety Disorders Behavior Behavioral Symptoms DNA Virus Infections Depression Herpesviridae Infections Infections Mental Disorders Nervous System Diseases Neuralgia Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms Varicella Zoster Virus Infection Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Tongji hospital

Wuhan, Hubei, 430031, China

Location status: Recruiting

Location contact

Yang Shuguang, Master

CONTACT

[email protected]

15071078161

About this study

Patients with herpes zoster neuralgia will be recruited and take Hospital anxiety depression rating scale (Hospital anxiety and 'scale, HADS) evaluation. According to the HADS Scores, patients will be divided into depression group and no depression, or anxiety group and no anxiety group. The clinical data the of two groups will be collected and statistically analyzed to explore the risk factors of anxiety and depression, including the changes of serum biomarkers and functional brain magnetic resonance imaging in patients with herpes zoster neuralgia accompanying anxiety or depression.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age more than 18 years old
  • Diagnosed as herpes zoster neuralgia
  • Signing informed consent

Exclusion criteria

  • Unable to complete the scale assessment
  • History of mental illness

Treatment and study plan

Hospital Anxiety and Depression Scale

Diagnostic Test

Hospital Anxiety and Depression Scale questionnaire is used to test patients for anxiety and depression.

Primary outcomes

  1. HADS score

    Time frame: during hospital stay, average of 1 week

    Enrolled patients will be first evaluated by Hospital Anxiety and Depression Scare questionaire and according to the HADS score, patients will be divided to group with anxiety/depression and group without anxiety/depression.

Secondary outcomes

  1. Interleukin (IL）-1β plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-1β （pg/ml）will be tested.

  2. IL-2 receptor plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-2 （u/ml）will be tested.

  3. IL-6 plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-6 （pg/ml）will be tested.

  4. IL-8 plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-8 （pg/ml）will be tested.

  5. IL-10 plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines IL-10 （pg/ml）will be tested.

  6. Interferon(INF)-α plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of inflammatory cytokines INF-α （pg/ml）will be tested.

  7. Brain-derived neurotrophic factor (BDNF) plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of BDNF（pg/ml）will be tested.

  8. C-reactive protein (CRP) plasma level

    Time frame: during hospital stay, average of 1 week

    Blood sample will be obtained from enrolled patients and the plasma level of CRP（mg/ml）will be tested.

  9. Area under curve (AUC) of topological metrics of functional brain magnetic resonance imaging

    Time frame: during hospital stay, average of 1 week

    Functional brain magnetic resonance imaging will be performed in patients with anxiety or depression, and area under curve (AUC) of topological metrics including Eglob,Eloc,Cp,Lp,γ,λ and σ will be calculated and analyzed.

Study contacts

Contact information is provided by the study sponsor or research team.

Mei wei, M.D, PhD

CONTACT

[email protected]

(+86)13006162508

Yang Shuguang, M.D

CONTACT

[email protected]

（+86）15071078161

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Registry information

Official study title

Risk Factors Analysis of Anxiety and Depression in Patients With Herpes Zoster Neuralgia and Characteristics of Serum Biomarkers and Functional Brain Magnetic Resonance Changes

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Jun 10, 2024
Registry last updated
Aug 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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