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Completed

NCT Number: NCT04533802

Risk Factors for Stress-induced Alcohol Misuse: Genetic Predictors and Mediation by Personality Type

To examine whether variation in 'risk-taking' personality and linked genetic variants predicts susceptibility to, and resilience against, stress-induced alcohol misuse.

Completed

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Key information

Conditions

Alcohol Use, Unspecified Alcohol Drinking Behavior Drinking Behavior

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Portsmouth University Hospital

Portsmouth, Hampshire, PO63LY, United Kingdom

About this study

Alcohol misuse is a global health issue responsible for over 1 million hospital admissions per annum in the UK with a combined cost of approximately £21 billion. Chronic alcohol misuse in patients who attend hospital for alcohol-related illness/injury is common, with relapse and recidivism almost ubiquitous. Patients often report that 'stress' was a catalyst for their drinking episodes, but we do not know exactly who is most at risk, how stress leads to drinking, or the genetic basis for this risk. This research aims to seek to identify patients at higher risk of stress-induced alcohol misuse, or who are more resilient to stress in this context, using a combination of analyses ranging from genetic variants to personality tests and clinical follow-up. The ultimate goal is that patients engaging with alcohol services can receive personalised and focussed treatment and enhance recovery

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female, aged (min) 18 years
  • Attended Portsmouth Hospitals University Trust following illness/injury related to alcohol use
  • Has a maximum AUDIT score of 15
  • Is willing and able to comply with study procedures
  • Willing and able to give informed consent for participation in the study.
  • Must be recruited within 24 hrs of ASNS referral, and able to be tested within 48 hours of referral

Exclusion criteria

ny reported/suspected intellectual/learning disabilities (e.g., Down's Syndrome), neurodevelopmental disorders (e.g., Autism, Asperger's) or acquired brain injury

  • Has previously participated in this study
  • Should not be under the influence of alcohol during the study (12hrs previous to taking part) - to be determined via breathalyser.
  • Any history of advanced liver disease (clinical diagnosis of cirrhosis, jaundice, encephalopathy, ascites, variceal haemorrhage)

Treatment and study plan

Primary outcomes

  1. Alcohol misuse

    Time frame: immediately after the procedure

    Measured using the alcohol use disorders identification test (AUDIT) (higher the score the worse the outcome)

  2. Recent stressors

    Time frame: Immediately after the study visit

    Measured using the 30 item Stress Overload Scale questionnaire (higher the score, the worse the outcome)

  3. Life Events

    Time frame: Immediately after the study visit

    Measured using the Life Events Checklist Questionnaire (the higher the score the worse the outcome)

  4. Impulse Behaviour

    Time frame: Immediately after the study visit

    Measured using the the Urgency, Premeditation (lack of), Perseverance (lack of), Sensation Seeking, Positive Urgency, Impulsive Behavior Scale (UPPS-P) higher values indicate more impulsive behavior.

  5. Risk taking behaviour

    Time frame: Immediately after the study visit

    Measured by the Stop Signal Reaction Time Task (computer task) which measures the ability to inhibit a planned response

  6. Molecular Anaylsis

    Time frame: Immediately after the study visit

    Cheek swabs will be taken from all participant to carry out genomic DNA analysis

Sponsors and collaborators

Lead sponsor

Portsmouth Hospitals NHS Trust

Other Gov

Collaborators

  • University of Portsmouth

Registry information

Official study title

Personality and Genotypic Markers That Predict Individual Differences in Susceptibility to Stress-induced Alcohol Misuse: a Feasibility Study.

Acronym: RISK

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Sep 1, 2020
Registry last updated
Apr 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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