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NCT Number: NCT04935086

Risk Factors for Predictors of MACEs After RA-CABG

As the secondary choice of artery grafts, radial artery is more and more used to achieve multiple arterial revascularization in CABG. Risk factors for predictors of major cardiovascular adverse events (MACE) after CABG using radial-artery grafts (RA-CABG), however, remain uncertain. This case-control study aims to identify the baseline predictors of MACE after RA-CABG.

We will collect the baseline characteristics and perioperative data of patients underwent RA-CABG from Jan. 2009 to Dec. 2019 in our single center. By reviewing the latest follow-up records, we will examine the correlation between the baseline characteristics and clinical outcomes (MACEs), then identify the independent risk factors for predictors of MACEs after RA-CABG.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Ruijin Hospital Shanghai Jiao Tong University School of Medicine

Shanghai, Shanghai Municipality, 200025, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Underwent CABG using at least a radial artery grafts from Jan.2009 to Dec.2019. with or without cardiopulmonary bypass , with or without concomitant procedure
  • Aged 18 and above at procedure
  • With any gender

Exclusion criteria

  • With unavailable medical records

Treatment and study plan

Primary outcomes

  1. 7-day MACE-4

    Time frame: 7 days post-CABG

    a composite of all-cause death, myocardial infraction, stroke and repeat revascularization

  2. 30-day MACE-4

    Time frame: 30 days post-CABG

    a composite of all-cause death, myocardial infraction, stroke and repeat revascularization

  3. 1-year MACE-4

    Time frame: 1 year post-CABG

    a composite of all-cause death, myocardial infraction, stroke and repeat revascularization

  4. 3-year MACE-4

    Time frame: 3 years post-CABG

    a composite of all-cause death, myocardial infraction, stroke and repeat revascularization

Secondary outcomes

  1. MACE-3

    Time frame: 7 days, 30 days, 1 year, and 3 years post-CABG

    a composite of CV-death, myocardial infraction and stroke

  2. All-cause death

    Time frame: 7 days, 30 days, 1 year, and 3 years post-CABG

    Death from any cause

  3. CV-death

    Time frame: 7 days, 30 days, 1 year, and 3 years post-CABG

    Including death resulting from an acute myocardial infarction , sudden cardiac death, death due to heart failure, death due to stroke, death due to cardiovascular procedures, death due to cardiovascular hemorrhage, and death due to other cardiovascular causes

  4. Myocardial infraction

    Time frame: 7 days, 30 days, 1 year, and 3 years post-CABG

    According to the 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials, including CABG-related MI, non CABG-related MI, silent MI and unknown type.

  5. Stroke

    Time frame: 7 days, 30 days, 1 year, and 3 years post-CABG

    According to the 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials, including ischemic, hemorrhagic and unknown type.

  6. Repeat revascularization

    Time frame: 7 days, 30 days, 1 year, and 3 years post-CABG

    According to the 2017 Cardiovascular and Stroke Endpoint Definitions for Clinical Trials, including any PCI and CABG.

Sponsors and collaborators

Lead sponsor

Ruijin Hospital

Other

Registry information

Official study title

Risk Factors for Predictors of Major Adverse Cardiovascular Events After Coronary Artery Bypass Using Radial Artery Grafts

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Jun 22, 2021
Registry last updated
Dec 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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