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Completed

NCT Number: NCT07674992

Risk Factors for PICC-Related Infection in 994 High-Risk Patients: The Role of Hb Levels and Sampling Frequency

This retrospective cohort study aims to evaluate the incidence and clinical predictors of Central Line-Associated Bloodstream Infections (CLABSI) in patients receiving Peripherally Inserted Central Catheters (PICCs) via the Anesthesia Department.

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Key information

Conditions

CLABSI - Central Line Associated Bloodstream Infection Catheter-Related Infections Infections

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Siriraj Hospital

Bangkok Noi, Bangkok, 10700, Thailand

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with PICC line more than 48 hours, performed by Anesthesia Department from January 2023 to December 2024

Exclusion criteria

  • Incomplete data
  • Patient with reported colonization of PICC line
  • Patient with unintended position of PICC line
  • Patient with any other central venous catheter besides PICC line
  • Patient with previously reported as CLABSI

Treatment and study plan

Hemoglobin level

Other

Hb ≤ 9.6 g/dL

Primary outcomes

  1. rate of CLABSI

    Time frame: From January 2023 to December 2024

    incidence of CLABSI

Secondary outcomes

  1. Study the risk factors related to CLABSI, including clinical factors, comorbidities, indication for PICC, and laboratory.

    Time frame: From January 2023 to December 2024

    To evaluate potential risk factors for CLABSI, baseline demographic, clinical, and procedural characteristics will be collected at PICC line insertion and analyzed using two aggregated formats: continuous variables will be reported as means (with SD) or medians (with IQR): age (years), weight (kg), height (m), combined BMI (kg/m^2), procedure duration (minutes), catheter indwelling time (days), hemoglobin (g/dL), and white blood cell counts (cells/µL). Categorical variables will be reported as percentages/proportions: sex, ICU admission, preprocedural antibiotics, procedure duration <60 minutes, indwelling time ≤6 weeks, comorbidities (immunocompromised, hypertension, liver disease, diabetes, oncologic/hematologic malignancies), and insertion indications (TPN, CMT, prolonged IV meds, frequent blood sampling, vasopressors). All variables will be analyzed via regression to identify independent predictors of CLABSI.

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Risk Factors for PICC-Related Infection in 994 High-Risk Patients: The Role of Hb Levels and Sampling Frequency-A Retrospective Cohort Study

Important dates

Study start
2023
Primary completion
2025
Study completion
2026
First posted
Jun 30, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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