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NCT Number: NCT07042321

Risk Factors for Microvascular Obstruction Post-Emergency PCI in AMI Patients

The goal of this prospective cohort study is to investigate the relationship between the TyG index and early identification of MVO in AMI patients undergoing emergency PCI and CMR imaging. The study will enroll approximately 300 AMI patients treated at Xiangya Third Hospital of Central South University from June 2024 to August 2025. The main questions it aims to answer are:

* How does the TyG index correlate with the early detection of MVO? * What differences in cardiovascular adverse events during hospitalization exist between groups with varying TyG index levels? Participants will undergo emergency PCI and CMR imaging within 3-7 days post-procedure. Data collected will include demographic characteristics, clinical history, coronary angiography data, laboratory test indicators (especially metabolic markers such as blood glucose and lipids), IVUS-related plaque information, and CMR results.

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Key information

Conditions

Acute Myocardial Infarction (AMI)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Xiangya Third Hospital of Central South University

Changsha, Hunan Province,China, 410013, China

Location status: Recruiting

Location contact

灿 Zhu Can

CONTACT

[email protected]

+8613348674820

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years.
  • STEMI symptom onset time < 12 hours.
  • STEMI symptom onset time 12-48 hours, with ongoing ischemic symptoms, hemodynamic instability, or life-threatening ventricular arrhythmias.
  • Very high-risk NSTEMI; undergoing emergency PCI treatment.
  • Voluntary signed informed consent form.

Exclusion criteria

  • Non-obstructive acute myocardial infarction.
  • Severe chronic kidney disease (defined as estimated glomerular filtration rate <20 mL/min per 1.73 m²).
  • Pregnant women or those planning to become pregnant.
  • Failure of emergency PCI.
  • Unclear CMR images

Treatment and study plan

Primary outcomes

  1. The presence or absence of microvascular obstruction (MVO) diagnosed by cardiac magnetic resonance (CMR) within 3-7 days postoperatively

    Time frame: 3-7 days postoperatively

Study contacts

Contact information is provided by the study sponsor or research team.

can Zhu Can

CONTACT

[email protected]

+8613348674820

Sponsors and collaborators

Lead sponsor

The Third Xiangya Hospital of Central South University

Other

Registry information

Official study title

Triglyceride Glucol Index for Predicting the Value of No-Reflow in Patients Undergoing Emergency PCI for Acute Myocardial Infarction

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jun 29, 2025
Registry last updated
Jul 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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