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OpenTrials
Completed

NCT Number: NCT07050199

Risk Factors Affecting Mortality in Perforated Peptic Ulcer

Perforation is one of the most severe and life-threatening complications of peptic ulcer disease. This study aims to evaluate the risk factors associated with postoperative morbidity and mortality in patients undergoing surgery for peptic ulcer perforation, with a focus on the timing of presentation, demographic variables, surgical delay, and their association with postoperative outcomes.

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Key information

Conditions

Peptic Ulcers Digestive System Diseases Duodenal Diseases Gastrointestinal Diseases Intestinal Diseases Peptic Ulcer Stomach Diseases

Age range

15 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

National Medical College and Teaching Hospital

Birgunj, 44600, Nepal

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with peptic ulcer perforation aged> 15 years and <75 years.
  • Patients with duodenal or gastric perforation of peptic ulcer origin.
  • Patients who underwent simple closure with omental patch as a standard operative procedure.

Exclusion criteria

  • Patients treated with conservative management.
  • Patients with perforation of peptic ulcer origin at the jejunum, ileum adjacent to Meckel's diverticulum.
  • Patients presenting with recurrent perforation or stomal ulcer perforation.

Treatment and study plan

Emergency laparotomy

Procedure

Emergency laparotomy

Primary outcomes

  1. Postoperative Morbidity Rate

    Time frame: 12 months (from patient enrollment to completion of follow-up)

    Incidence of postoperative complications (e.g., wound infection, sepsis, anastomotic leak, pneumonia) in patients undergoing surgery for perforated peptic ulcer.

  2. Postoperative Mortality Rate

    Time frame: 12 months (from patient enrollment to completion of follow-up)

    Incidence of death following surgical intervention for perforated peptic ulcer.

Sponsors and collaborators

Lead sponsor

Maharajgunj Medical Campus

Other

Registry information

Official study title

Risk Factors Affecting Morbidity and Mortality in Perforated Peptic Ulcer

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jul 3, 2025
Registry last updated
Jul 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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