RISE FOR HEALTH Study

The RISE FOR HEALTH study (RISE) is an initiative of the Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium, which was formed by the NIDDK in 2015 to develop the science to improve bladder health in women and girls. RISE is designed to identify risk and protective factors for bladder health and lower urinary tract symptoms (LUTS) and to estimate the distributions of bladder health and bladder health knowledge, attitudes, and beliefs in women of all ages across the life course.

This will be accomplished by conducting a population-based prospective cohort study. A sample of individuals who live within the study base, i.e., the county containing each PLUS clinical research center and each adjacent county, will be invited to complete two baseline surveys and then two follow-up surveys one year later. A subset of participants will be invited to attend an in-person evaluation to collect additional clinical information and biologic specimens.

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Key information

Conditions

Lower Urinary Tract Symptoms Pathological Conditions, Signs and Symptoms Signs and Symptoms Urological Manifestations

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alabama at Birmingham, Birmingham, Alabama, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Community dwelling
Age ≥18 years
Identify or born as female (includes cis- and trans-women, and trans-men)
Able to read and understand English or Spanish
Able to read and provide informed consent

Exclusion criteria

Physical or mental health conditions that would prohibit self-administration of questionnaires either electronically or using paper and pencil (e.g., dementia/cognitive impairment/blindness/severe arthritis).
Residence in a nursing home or other institutionalized living facility.

Treatment and study plan

Primary outcomes

Bladder Health Scales and Function Indices

Time frame: Baseline assessment

Multi-item measurement to assess bladder health comprised of subscales and indices ranging from zero to 100

Secondary outcomes

Knowledge, Attitudes and Beliefs (KAB)

Time frame: Baseline assessment

Several questions on knowledge, attitudes, and beliefs regarding bladder health and influences on bladder health
Change in Bladder Health Scales and Function Indices

Time frame: 1 year follow-up from baseline assessment

Change in multi-item measurement to assess bladder health comprised of subscales and indices ranging from zero to 100

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Collaborators

Emory University
Loyola University Chicago
Northwestern University
University of Alabama at Birmingham
University of California, San Diego
University of Michigan
University of Pennsylvania
Washington University School of Medicine
Yale University

Registry information

Official study title

RISE FOR HEALTH Study by the PLUS Consortium

Important dates

Study start: 2022
Primary completion: 2023
Study completion: 2025
First posted: May 9, 2022
Registry last updated: Aug 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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