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Completed

NCT Number: NCT03165032

Right Ventricular Function During Exercise in Highlanders/Lowlanders

The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by performing a cross-sectional case-control study.

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Key information

Conditions

High Altitude Pulmonary Hypertension Behavior Cardiovascular Diseases Hypertension Hypertension, Pulmonary Hypoxia Lung Diseases Motor Activity Pathological Conditions, Signs and Symptoms Pulmonary edema of mountaineers Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory Vascular Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

National Center for Cardiology and Internal Medicine

Bishkek, 720040, Kyrgyzstan

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • high altitude pulmonary hypertension confirmed by clinical presentation and mean pulmonary artery pressure >30 mmHg measured by echocardiography at altitude of residence.
  • healthy subjects (high altitude controls)
  • Both genders
  • Age >16 y
  • Kyrgyz ethnicity
  • born, raised and currently living at >2500 m
  • healthy subjects currently living at <1000 m (low altitude controls)

Exclusion criteria

  • Pulmonary hypertension from other causes, in particular from left ventricular failure as judged clinically and by echocardiography
  • Excessive erythrocytosis
  • Other coexistent disorders that may interfere with the cardio-respiratory system and sleep
  • Regular use of medication that affects control of breathing
  • Heavy smoking

Treatment and study plan

Primary outcomes

  1. pulmonary artery pressure (PAP) during exercise

    Time frame: Day 2

    Difference in change of tricuspid pressure gradient during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

Secondary outcomes

  1. cardiac output (CO) during exercise

    Time frame: Day 2

    Difference in change of cardiac output during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

  2. PAP/CO slope during exercise

    Time frame: Day 2

    Difference in change of PAP/CO slope during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

  3. Oxygen saturation

    Time frame: Day 2

    Difference in change of oxygen saturation during exercise between highlanders with pulmonary hypertension, healthy highlanders and healthy lowlanders, measured by transthoracic echocardiography during graded cycling on an ergometer

Sponsors and collaborators

Lead sponsor

University of Zurich

Other

Collaborators

  • National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov

Registry information

Official study title

Right Ventricular Function During Exercise in Highlanders With Pulmonary Hypertension Compared to Highlanders Without Pulmonary Hypertension and Lowlanders

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
May 24, 2017
Registry last updated
Aug 16, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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