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NCT Number: NCT07619274

Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery

Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.

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Key information

Conditions

Respiratory Acidosis in ICU Patients Hemodynamic Changes Mechanical Ventilation Right Ventricular (RV) Dysfunction

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval

Québec, Quebec, G1V4G5, Canada

About this study

Post hoc analysis of data from two separate studies previously approved by the Research Ethics Board NCT05886413 and NCT06826794. A stratification according to respiratory acidosis defined by a pH <7.35 with PaCO₂ >45mmHg on the first arterial blood gas analysis at the intensive care unit arrival will be done.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Previously included and complete study NCT05886413 or NCT06826794

Exclusion criteria

  • Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output
  • Absence of arterial blood gas on arrival to the intensive care unit

Treatment and study plan

Not applicable- observational study

Other

No intervention

Primary outcomes

  1. Right ventricular function per central hemodynamic assessment

    Time frame: At intensive care unit admission - within the first 4 hours

    Calculation of different predictor: Cardiac index, PAPi (pulmonary artery pulse pressure over central venous pressure) , RVSWI ((mean pulmonary artery pressure- central venous pressure) X stroke volume index X 0.0136) and RV-CPO

Secondary outcomes

  1. Intensive care unit length of stay

    Time frame: Up to 28 days

    Intensive care unit admission through Intensive care unit discharge

  2. Mechanical ventilation duration

    Time frame: Day 28

    Time spent with invasive mechanical ventilation between intensive care unit admission and hospital discharge

  3. Vasopressor duration

    Time frame: Day 28

    Duration of vasopressor or inotrope administration

  4. Acute renal failure

    Time frame: Day 28

    Rate of acute renal failure during coronary unit length of stay. Renal failure will be defined according to the usual criteria, i.e., an increase of >27 umol/L creatinine in 48 hours or 1.5x over the baseline

  5. Mortality

    Time frame: Day 28

    Mortality in intensive care unit

Study contacts

Contact information is provided by the study sponsor or research team.

Etienne Couture

CONTACT

[email protected]

1-418-656-8711

Sponsors and collaborators

Lead sponsor

Laval University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 1, 2026
Registry last updated
Jun 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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