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Completed

NCT Number: NCT05407363

Ridge Augmentation With Simultaneous Implant Placement Using Bone Blocks With Autogenous Tooth Graft

Autogenous bone, with its osteogenic, osteoinductive, and osteo-conductive characteristics has been used for bone grafts with optimal integration into host tissues. For this reason, autogenous bone has been often considered the gold standard of bone regeneration material. However, the amount of autogenous bone that may be harvested is limited, and the harvesting procedure is traumatic.

Bone substitutes, including allografts, xenografts, and alloplasts have been used successfully as alternatives to autogenous bone grafts in ridge augmentation procedures.

In 2008, autogenous tooth bone graft (ATG) was introduced and used for the first time as a bone grafting material for GBR. The tooth contents are extremely similar to that of the alveolar bone. The enamel inorganic, organic, and water contents are 95 percent, 0.6 percent, and 4 percent, respectively. However, in the dentin, the percentages are 70 to 75 percent, 20 percent, and 10 percent, respectively. They are 65 percent, 25 percent, and 10 percent, respectively, when compared to the alveolar bone content.

The aim of this study is to compare ridge augmentation using autogenous bone block (ABB) with immediate implant placement and filling the generated gap with autogenous bone graft (ABG) or ATG, or ridge augmentation using xenograft bone block (XBB) with immediate implant placement and filling the generated gap with ATG.

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Key information

Conditions

Ridge Augmentation Autogenous Tooth Graft Implant

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Kafrelsheikh University

Kafr ash Shaykh, 33511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Teeth with buccal bone destruction by periodontal disease and need extraction (horizontal or vertical bone defect);
  • Absence of acute inflammation;
  • Absence of uncontrolled systemic illness that would preclude implantation;
  • Good dental and systemic healthy conditions;
  • Patients were willing and able to return for multiple follow-up visits.

Exclusion criteria

  • Patients with systemic illnesses,
  • psychological abnormalities,
  • para-functional habit,
  • smokers or alcoholics,
  • pregnant and lactating patients,
  • patients undergoing or recently completed radiotherapy or chemotherapy,
  • patients on drugs affecting the healing process,
  • patients with endodontically treated teeth

Treatment and study plan

ABB and ATG with simultaneous implant placement

Procedure

Ridge augmentation using ABB and ATG as a graft material with simultaneous implant placement

XBB and ATG with simultaneous implant placement

Procedure

Ridge augmentation using XBB and ATG as a graft material with simultaneous implant placement

ABB and ABG with simultaneous implant placement

Procedure

Ridge augmentation using ABB and ABG as a graft material with simultaneous implant placement

Primary outcomes

  1. Clinical evaluation probing pocket depth and amount of bone around simultaneously placed dental implants

    Time frame: 9 months

    Changes on pocket depth and amount of bone using ABG or ATG with ABB or XBB around simultaneously placed dental implants

  2. radiographic outcome measuring the amount of bone around simultaneously placed dental implants

    Time frame: 9 months

    the radiographic outcome by measuring the amount of bone by using ATG or ABG on bone formation with ABB or XBB around simultaneously placed dental implants

Sponsors and collaborators

Lead sponsor

Kafrelsheikh University

Other

Registry information

Official study title

Ridge Augmentation With Simultaneous Implant Placement Using Xenogenic Blocks or Autogenous Bone Blocks With Autogenous Tooth Graft

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Jun 7, 2022
Registry last updated
Dec 22, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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