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NCT Number: NCT07642193

Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy

This study aims to compare time of first request of analgesia among patients undergoing rhomboid intercostal sub-serratus plane block versus external oblique intercostal block for perioperative pain management in open nephrectomy.

Recruiting

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

Open nephrectomy is a common surgery usually performed for malignant and non-malignant renal pathologies. Open nephrectomy incision is associated with a high incidence of intense immediate postoperative pain and chronic pain the months following surgery.

The rhomboid intercostal block has previously been used for pain management in thoracic wall surgery.

Subserratus plane block in the treatment of post-abdominal surgical pain and the combination of the two blocks was subsequently renamed the "RISS block". The nerves targeted by the RISS block include the lateral cutaneous branches of the ventral branches of the thoracic intercostal nerves, located between the rhomboid muscle and the intercostal muscles, and deep into the scapula serratus anterior muscle. RISS block provides analgesia from T4 to T9 thoracic dermatomes and has been used in postoperative pain management for thoracic surgeries and upper abdominal surgeries.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both sexes.
  • American Society of Anesthesiologists (ASA) physical status II, III.
  • Body mass index (BMI): > 20 kg/ m2 and < 35 kg/ m2.
  • Patients undergoing open nephrectomy.

Exclusion criteria

  • Patient refusal.
  • BMI <20 kg/m2 and >35 kg/m2
  • Known sensitivity or contraindication to drug used in the study (local anesthetics, opioids).
  • History of psychiatric and cognitive disorders or chronic pain.
  • Contraindication to regional anesthesia e.g pre- existing peripheral neuropathies.
  • Severe respiratory or cardiac disorders.
  • Advanced liver or kidney disease.
  • Pregnancy.
  • Physical status ASA IV.
  • Coagulopathy with INR ≥ 1.6: hereditary (e.g. hemophilia, fibrinogen abnormalities & deficiency of factor II) - acquired (e.g. impaired liver functions with prothrombin concentration less than 60 %, vitamin K deficiency & therapeutic anticoagulants drugs).

Treatment and study plan

Rhomboid intercostal subserratus plane block

Other

Patients will receive the rhomboid intercostal subserratus plane block.

External oblique intercostal block

Other

Patients will receive the external oblique intercostal block.

intravenous morphine

Drug

Patients will not receive any interventions (Intravenous morphine 0.1mg/kg after induction of general anesthesia).

Primary outcomes

  1. Time of first request of analgesia

    Time frame: 24 hours postoperatively

    Time of first request of analgesia will be recorded from the end of surgery till first dose of morphine administrated.

Secondary outcomes

  1. Heart rate

    Time frame: 24 hours postoperatively

    Heart rate will be noted immediately on arrival and at 0, 4, 8, 12, 18 and 24 h postoperatively.

  2. Mean arterial blood pressure

    Time frame: 24 hours postoperatively

    Mean arterial blood pressure will be noted immediately on arrival and at 0, 4, 8, 12, 18 and 24 h postoperatively.

  3. Total amount of fentanyl

    Time frame: 24 hours postoperatively

    Fentanyl 0.5 μg / kg will be given in case of heart rate or mean arterial blood pressure ≥ 20% of the baseline

  4. Total morphine consumption

    Time frame: 24 hours postoperatively

    Intravenous morphine (3 mg) will be provided as rescue of analgesia. The total amount of morphine given in 24 h will be recorded.

  5. Degree of pain

    Time frame: 24 hours postoperatively

    Each patient will be instructed about postoperative pain assessment with the numeric rating scale (NRS) score. NRS (0 represents "no pain" while 10 represents "the worst pain imaginable"). NRS will be recorded at 30 minutes, 2,4, 8, 12, 16, 24 hours postoperatively.

  6. Incidence of block related complications

    Time frame: 24 hours postoperatively

    Incidence of block related complications such as local anesthetic toxicity, hematoma formation, and pneumothorax will be recorded.

Study contacts

Contact information is provided by the study sponsor or research team.

Amr R Seif, MD

CONTACT

[email protected]

00201066588692

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Ultrasound Guided Rhomboid Intercostal Sub-serratus Plane Block Versus External Oblique Intercostal Block in Open Nephrectomy: Randomized Controlled Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 11, 2026
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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