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OpenTrials
Completed

NCT Number: NCT06510023

Rewards Sensitivity After Brain Injury

A study measuring rewards sensitivity in individuals with acquired brain injury at an acute rehabilitation level.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Shirley Ryan AbilityLab

Chicago, Illinois, 60611, United States

About this study

Individuals in acute rehabilitation following acquired brain injury journal (ABI) and aged-matched, non-injured controls will be recruited for this study.

Testing sessions will take place in a private treatment room at the Shirley Ryan AbilityLab and required 45 minutes to complete. Upon entering the room, participants will be greeted, electrodes placed on the participant's fingers to record their electrodermal activity, and participants will provide demographic information. Participants will then be instructed about how to respond on the Cued Reinforcement Response Time task (CRRT, see description below), and complete the task on a laptop computer while their electrodermal activity is being recorded. In this task, they are instructed to respond as quickly and accurately as possible, and will be informed that they will receive a monetary reward based on their accuracy at the completion of the task. Finally, participants will complete 3 self-report measures: (1) explicit level of motivation was measured in a post-study survey which included two items from the Sensitivity to Punishment and Sensitivity to Reward Questionnaire, (SPSRQ); (2) Reward sensitivity was evaluated using the Reward Responsiveness Scale , and (3) depression was evaluated using the Patient Health Questionnaire (PHQ-8) survey. At the end of the session, the electrodes will be removed, and participants will be debriefed and provided their monetary reward

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Individuals with ABI
  • Diagnosis of Traumatic Brain Injury or Stroke, based on their medical records
  • Age between 18-100
  • Able to follow directions in English (measured informally during screening)
  • Able to use at least one upper extremity (demonstrated by holding a pen)
  • Mild-moderate or lesser diagnosis in cognitive-communication area
  • Score of 25 or higher on the Orientation Log assessment
  • Able to consent for participation in study (identifies through chart review)
  • Capable of understanding and cooperating with the experimental procedures.

Healthy participants

  • Age of 18 to 100 years old
  • Ability to follow directions in English
  • Ability to use at least one upper extremity.

Exclusion criteria

  • Individuals with ABI
  • Additional diagnosis of a neurological disorder other than ABI
  • Additional diagnosis of aphasia.
  • Having cognitive or behavioral impairments that preclude participation in the experimental procedures

Healthy Participants

  • history of significant cerebrovascular or neurological disease including (but not limited to) meningitis, epilepsy and/or seizures, stroke, tumor, multiple sclerosis, meningitis, mental retardation, dementia.

Treatment and study plan

Type of reward presented

Behavioral

Three different types of rewards were presented to both groups during the computerized task: one dollar, one penny, and no reward.

Primary outcomes

  1. Performance on a Cued Response Reaction Time Task, in each of the three rewards conditions (Dollar, Penny, No reward)

    Time frame: 15 minutes

    Accuracy (percentage of correct responses) in a Cued Response Reaction task

  2. Performance on a Cued Response Reaction Time Task, in each of the three rewards conditions (Dollar, Penny, No reward)

    Time frame: 15 minutes

    Response time (time in milliseconds) in a Cued Response Reaction task

  3. Electrodermal activity (EDA) before, during and after the Cued Response Reaction task

    Time frame: 30 minutes

    Number of skin conductance responses (SCRs) before, during and after the task

Sponsors and collaborators

Lead sponsor

Shirley Ryan AbilityLab

Other

Registry information

Official study title

Preserved Reward Sensitivity During Acute Rehabilitation Following Acquired Brain Injury

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Jul 19, 2024
Registry last updated
Jul 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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