Reversibility of Minimal Hepatic Encephalopathy Following Liver Transplantation

This study included 20 patients listed for liver transplantation in addition to 20 age- and sex- matched controls. Neurological, psychiatric, laboratory and radiological examinations were performed for both patients and controls before and 6 months after liver transplantation. Assessment of cognitive functions by Trail Making Test A (TMT A), TMT B, Digit Symbol Test (DST), and Serial Dotting Test (SDT) was done before and after liver transplantation.

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Key information

Conditions

Minimal Hepatic Encephalopathy

Age range

18 year–55 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Right handed patients with biopsy-proven liver cirrhosis listed for liver transplantation

Exclusion criteria

Overt hepatic encephalopathy.
Significant cortical atrophy or other structural brain changes revealed by conventional neuro-imaging.
Regular use of psychotropic drugs, such as benzodiazepines.
Known major psychiatric disorder.
Less than 6 months of complete alcohol abstinence.
Post-transplant toxic levels of immunosuppressive drugs.
Patients unable to perform the tests (Illiterate or upper limb motor handicaps).

Treatment and study plan

Liver Transplantation

Procedure

Primary outcomes

Improvement of Psychometric tests.

Time frame: 6 months following liver transplantation.

Secondary outcomes

Improvement of liver functions and MELD score following liver transplantation.

Time frame: 6 months following liver transplantation.

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
First posted: May 10, 2016
Registry last updated: May 11, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed