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OpenTrials
Completed

NCT Number: NCT01924221

Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Cardiac resynchronization therapy with pacemaker alone, or in combination with a cardioverter-defibrillator, prolongs life and decreases risk of heart failure exacerbation in patients with low ejection fraction and wide QRS. Some patients achieve decrease in QRS duration 6 months after cardiac resynchronization therapy. Such phenomenon is called reverse electrical remodeling of native conduction. Retrospective analysis showed that reverse electrical remodeling of the native conduction after at least 6 months of CRT is associated with decreased rate of ventricular arrhythmias and better survival. This study is designed to study reverse electrical remodeling prospectively.

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases Patients Undergoing CRT-D Device Implantation

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients undergoing implantation of a CRT-D

Exclusion criteria

  • age < 18 y
  • pregnancy or planned pregnancy

Treatment and study plan

Primary outcomes

  1. correlation between electrical and mechanical remodeling

    Time frame: 6 months after CRT implantation

    correlation between electrical and mechanical measures of dyssynchrony

Sponsors and collaborators

Lead sponsor

Johns Hopkins University

Other

Registry information

Official study title

Study of Reverse Electrical Remodeling of Native Conduction in Cardiac Resynchronization Therapy

Acronym: RER-CRT

Important dates

Study start
2011
Primary completion
2022
Study completion
2022
First posted
Aug 16, 2013
Registry last updated
Aug 30, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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