Revascularization of Calcified Coronary Arteries

The primary aim of this study is to evaluate changes in absolute coronary flow and pressure before and after percutaneous coronary intervention in calcified lesions. The secondary aim is to use a machine learning model to predict the outcome of the intervention.

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Key information

Conditions

Coronary Arterial Disease (CAD) Cardiovascular Diseases Heart Diseases Ischemic Heart Disease (IHD) Myocardial Ischemia Percutaneous Coronary Intervention (PCI) Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aalborg University Hospital

Aalborg, Denmark

Location status: Recruiting

Location contact

Julie Juul Siig, MD

CONTACT

[email protected]

+45 97 66 00 00

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age > 18 years
Moderate (40-90 %) epicardial disease
Vessel suitable for PCI and intracoronary imaging
De novo-lesions

Exclusion criteria

eGFR < 40ml/min
ACS < 48 hours
Patient without ability to provide informed consent
Patient with left main stenosis
Indication for coronary artery bypass grafting

Treatment and study plan

Measurement of coronary flow and pressure

Diagnostic Test

The pressure and flow data will be integrated in a machine learning model

Primary outcomes

Post-PCI FFR

Time frame: Immediately after the procedure

FFR is measured after PCI is completed.

Study contacts

Contact information is provided by the study sponsor or research team.

Ashkan Eftekhari, MD PhD

CONTACT

[email protected]

+4597664465

Sponsors and collaborators

Lead sponsor

Aalborg University Hospital

Other

Registry information

Official study title

Percutaneous Coronary Intervention of Calcified Lesions and the Use of Artificial Intelligence to Predict Successful Outcome

Acronym: PICA

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2030
First posted: Jul 23, 2026
Registry last updated: Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed