Return to Activity After Total Knee Arthroplasty

This multicenter research project aims to correlate objective testing of muscle mass, muscle strength, neuromuscular activation, walking speed and other functional tests with everyday activity and subjective quality of life after total knee arthroplasty. For this purpose, 400 patients from 5 orthopedic departments in Germany and USA will be examined at the time points pre-op, six weeks, three, six and 12 months post-op.

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Key information

Conditions

Total Knee Arthroplasty

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Technical University Munich, Munich, Bavaria, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients receiving a total knee arthroplasty
Ability to perform the return to activity battery

Exclusion criteria

Inability to perform the return to activity battery

Treatment and study plan

Return to Activity Battery

Other

The main target parameters are muscle mass (sonography), muscle strength (isometric maximum strength measurement), neuromuscular activation (surface EMG), functionality (e.g. 6MWT, chair rising test), knee swelling and subjective assessment of everyday and leisure activities, quality of life (e.g. SF-36) and return to work

Primary outcomes

Muscle Mass

Time frame: Pre-OP to 12 months Post-OP

Sonographically Analysis of the M. quadriceps femoris
Muscle Strength

Time frame: Pre-OP to 12 Months Post-OP

Isometric maximal strength of the knee extensors

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Prospective, Multicenter Study of Clinical Rehabilitation and Return-to-activity After Total Knee Arthroplasty

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2027
First posted: Jun 5, 2025
Registry last updated: Jun 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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