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NCT Number: NCT06360185

Retrospective Study of Patients with Acute Presentation for Asthma to an Emergency Department in UK (RAPAE)

Study team will obtain a list of all patients who have been seen in A+E over the past 6 years with a discharge diagnosis of asthma. Their history will be reviewed from their A+E notes. Team will obtain weight and height from Electronic prescribing tool and will obtain compliance information and past medical history from participant's GP records. Team will use participant's postcode to word out socio economic status quintile using office of national statistics tool. The following information will be taken from hospital documentation and from GP records.

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Key information

Conditions

Age range

16 year–99 year

Sex eligibility

All sexes

Study type

Observational

About this study

  • How many previous admissions in past one year (12 months)
  • How many presentations to A+E in previous one year (12 months)
  • Diagnosis not confirmed therefore not on any ICS
  • Poor compliance (less than 75% of ICS and/or LABA and/or LAMA and/or leukotriene prescriptions picked up in past year)
  • Recent presentation and maintenance therapy not increased (primary care or secondary care issue)
  • Is patient overweight BMI
  • Is patient on hormonal therapy, OCP, HRT, male hormones
  • Social class quintile from post code of address using ONS calculator
  • Ethnically diverse (see appendix)
  • First Eosinophil count on index admission
  • Highest eosinophil count in past (ever) and date
  • Treatment for diabetes type 2
  • Treatment for diabetes type 1
  • Treatment for hypertension
  • Smoker ever (pack year) when gave up__________

After obtaining this information study team will use simple statistical methods such as frequency and associations with confidence intervals to investigate which factors are associated with frequency of presentation to A+E. They will ascertain the frequency of patients who are on maximum therapy and may benefit from biological therapy, especially if they have raised eosinophils in the past year.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All Asthmatics patients who attend Emergency department over 5 years

Exclusion criteria

  • None Asthmatics.

Treatment and study plan

Primary outcomes

  1. Change in body weight

    Time frame: 5 years

    Information will be taken from hospital documentation and from GP records.

  2. Change in body height

    Time frame: 5 years

    Information will be taken from hospital documentation and from GP records.

Study contacts

Contact information is provided by the study sponsor or research team.

Ashnish Sinha

CONTACT

[email protected]

Sadiyah Hand, FRPC

CONTACT

[email protected]

01603 289612 ext. 5612

Sponsors and collaborators

Lead sponsor

Norfolk and Norwich University Hospitals NHS Foundation Trust

Other

Registry information

Official study title

Retrospective Study Investigating the Clinical Characteristic of Patients with Acute Presentation for Asthma to the A+E Department in a Busy Acute Hospital in England UK in Era of Biological Therapy for Asthma Between Jan 2019 & Jan 2024

Acronym: RAPAE

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Apr 11, 2024
Registry last updated
Feb 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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