Retrospective Study of Bone Infection Due to Campylobacter Spp

Only 24 cases of Campylobacter bone and joint infection (BJI) have been reported worldwide between 1955 and 2008. Between 2010 and 2012, 7 cases were observed in two University hospitals in France. This increasing number of cases raises several issues. Are they the consequences of better detections and reporting, or are they reflecting any epidemiologic changes? For answering these questions, we performed a 10 year (2002-2012) retrospective multicenter (6 centers) study on BJI (native and implanted joints) due to Campylobacter species.

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Key information

Conditions

Campylobacter Infections Bacterial Infections Bacterial Infections and Mycoses Bone Diseases Bone Diseases, Infectious Gram-Negative Bacterial Infections Infections Musculoskeletal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU de Brest

Brest, 29609, France

About this study

Methods: By browsing the microbiological database of 6 BJI French reference centers, we collected all cases due to Campylobacter species between 2002 and 2012, including first and relapse cases. Clinical, microbiological and treatment features were analyzed using descriptive statistics.

Results: 14 episodes of BJI due to Campylobacter spp were identified in 10 patients. Mean age was 76.8 y.o. (63-96). Sex ratio M/F was 1.5. Nine patient had hip (n=6), knee (n=2), and shoulder (n=2) implants. Immunosuppression was observed in 6 patients (3 cancers, 1 cirrhosis, 1 rheumatoid arthritis, 1 corticosteroid treatment). During the 10 primary cases: all patients had fever and 2 presented digestive symptoms. Campylobacter spp were isolated on per operative samples in 5 patients. One of them presented positive blood culture. 5 patients had joint punctures: all of them were positives. Campylobacter species were C. fetus (n=7), C. coli (n=2) and C. spp (1). Strains were resistant to nalidixic acid (=10), ciprofloxacin (n=4), erythromycin (n=3) or cefotaxime (n=2). Only one C. fetus was susceptible to all antibiotics tested. Surgical treatment was performed in 8 patients (2 two-stage procedure, 6 irrigation). The mean duration of adapted antibiotherapy was 77 days (26-237). 3 out of 4 relapse cases were due to C. fetus. All were resistant to more than one antibiotic classes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient with peroperative bone samples positive to Campylobacter spp. between Jan 2002 and Dec. 2012
Adults over 18 yo
No opposition to the study expressed by the patient

Exclusion criteria

Adults below 18 yo
Spine infection to Campylobacter spp.
Outside of the timeframe of the study
No microbiologic data available
Opposition to the study expressed by the patient

Treatment and study plan

Primary outcomes

Incidence rate of reported prosthetic joint Campylobacter spp. Infections

Time frame: 1986 to 2013

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Collaborators

Centre de Référence des Infections Ostéo-Articulaires du Grand Ouest

Registry information

Acronym: CAMPYLO

Important dates

Study start: 2014
Primary completion: 2014
Study completion: 2015
First posted: Aug 31, 2016
Registry last updated: Aug 31, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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