Retrospective Evaluation of POCD Data of Studies From KAI, Charité - Universitätsmedizin Berlin

Mild / major neurocognitive disorder 3 (mild / major NCD 'Postoperative cognitive dysfunction (POCD)') and 12 months (mild / major NCD) postoperatively.

Postoperative cognitive dysfunction (POCD) is defined as relevant change in postoperative cognitive performance compared to baseline (preoperative) cognitive performance.

The MiniCog is used for cognitive screening. A cut-off value of <3 points is interpreted possible mild / major NCD. The Mini-Cog consists of a sub-test for word memory skills and a clock drawing test.

The Montreal Cognitive Assessment (MOCA) with cut-offs according to normative age-adjusted values is used as dementia screening. The MOCA consists of 13 items, which are rated on a scale from 0 to 30 points.

Mild / major neurocognitive disorder (mild / major NCD) 60months postoperatively.

The non-computerized neuropsychological trail making test is used as an indicator screening test for relevant cognitive changes after the operation. The cut-off is an increase in TMT-B test performance of> 55 seconds three and / or 12 months after the operation compared to the baseline value.

Results from patient neurocognitive assessment in a memory clinic are evaluated.

Technique to image the nervous system.

Establishment of a norm database for deriving normative data in a cooperation between the Clinial Research Unit Berlin/Institute of Health (BIH), the Department of Anesthesiology and Operative Intensive Care Medicine (CCM/CVK) at Charité Universitätsmedizin Berlin and Cambridge Cognition.

Perioperative cognitive disorders for different surgical cohorts are evaluated to describe domain-specific changes over time in formal cognitive tests. These analyzes are carried out in a joint evaluation with Monument Therapeutics as part of a cooperation agreement

Computerized cognitive data from CANTAB-research suite, CANTAB eclipse and CANTAB connect

Paper-based, non-computerized, cognitive test data are data from such as IQ equivalent (e.g. MWT-A), MMSE, MOCA, MMQ, Mini-Cog, etc.

Soci-economic information is collected by FIMA

Soci-economic information is collected by a questionnaire according to Nikolaus 1. Subscale

Comorbidities are new diagnoses from hospital records.

Comorbidity scores

Consumption of alcohol per week.

Consumption of tobacco and nicotine is measured by Fagerström Test for Cigarette Dependence (FTCD). Questionnaire scored 0-10 points with Total Score equal to the sum of all points

Level of education is measured by ISCED

Incidence of postoperative delirium is measured by DDS, DSM-V, CAM/CAM-ICU, NuDESC and Chart review

The Duration of postoperative Delirium is measured in days

Severity of delirium 1 is measured by Delirium Detection Score (DDS). The DDS is composed of eight criteria (orientation, hallucination, agitation, anxiety, seizures, tremor, paroxysmal sweating, and altered sleep- wake rhythm). Each item is cored 0,1,4, or 7 points for a possible total score of 0 to 56). Positive if >7.

Severity of delirium 2 is measured by Confusion assessment method-short (CAM-S). This is a CAM-based scoring system for delirium severity. The CAM-S uses the same items as the original CAM and rates each symptom 0 for absent, 1 for mild, or 2 for marked; acute onset of fluctuation receives 0 (absent) or 1 (present) (scored 0-10, higher worse).

Severity of delirium 3 is measured by DSR-R-98. DRS-R-98 is 16 items clinician rated scale. Total Item: 16 = 3 (for diagnosis) + 13 (for severity).

Severity of delirium 4 is measured by ICDSC. Give a score of "1" to each of the 8 items below if the patient clearly meets the criteria defined in the scoring instructions. Give a score of "0" if there is no manifestation orunable to score. If the patient scores >4, notify the physician. The diagnosis of delirium is made following clinical assessment. assessment.

Severity of delirium 5 is measured by Nursing Delirium Screening Scale (Nu-DESC). The Nu-DESC is a scale that evaluates the severity of the 5 delirium characteristics on a scale of 0 (not present) to 2 (severe) and takes only 1-2 min to complete, based on the nurses' observations of the patient's behavior during their shifts.

Participants will be followed for the duration of hospital stay, an expected average of 7 days

Quality of life is measured by CarerQoL

Quality of life is measured by EQ-5D.An index calculated from the five EQ-5D (3L and 5L) dimensions by attaching specific weights to each severity level in each dimension.

Quality of life is measured by WHO-5. WHO-5 is a short and generic global rating scale measuring subjective well-being, the respondent is asked to rate how well each of the 5 statements applies to him or her when considering the last 14 days. Each of the 5 items is scored from 5 (all of the time) to 0 (none of the time). The raw score ranges from 0 (absence of well-being) to 25 (maximal well-being). Scores are then converted to a percentage scale from 0 (absent) to 100 (maximal). Higher scores represent greater psychological well-being.

Instrumental Activities of Daily Living (IADLs) < 8

Activities of Daily Living (ADLs) < 100

Depression 1 is measured by PHQ-8

Depression 2 is measured by GDS

Anxiety is measured by GAD-7

Pain is measured by different scales, e.g. Numeric Rating Scale

The sedation is emasured intraoperatively processed electroencephalogram (EEG) Full-brain EEG recording with surface electrodes, raw EEG analysis measured during the operation.

Sedation is measured by the Richmond Agitation Sedation Scale

Type of operation is measured by OPS-Code.

There are four main categories of anesthesia used during surgery and other procedures: general anesthesia, regional anesthesia, sedation (sometimes called "monitored anesthesia care"), and local anesthesia.

The medication administered during the hospital stay is documented.

Measured by anticholinergic drug scale

Frailty is measured with a modified frailty score according to Fried´s frailty phenotype assessment.

Laboratory results in the hospital including hemoglobin, lymphocytes, total neutrophils, platelet count, white blood cell (WBC) count and inflammatory markers from blood samples.

Laboratory results in the hospital from serum samples

Laboratory results in the hospital from urine samples

Laboratory results in the hospital from stool samples

Electroencephalography (EEG)- Mapping with electrodes.

Nutritional status 1 is measured by calf circumference

Nutritional status 2 is measured by arm circumference

Nutritional status 3 is measured by changes in weight

Nutritional status 4 is measured by changes in body mass index

Nutritional status 5 is measured by questions regarding microbiome

Nutritional status 6 is measured by Medi-Score

Nutritional status 7 is measured by MNA-SF

Nutritional status 8 is measured by Sarcopenia, which is identified by criterion 1: low muscle strength, criterion 2: low muscle quantity and criterion 3: low physical performance. Probable sarcopenia is identified by Criterion 1. Diagnosis is confirmed by additional documentation of Criterion 2.

If Criteria 1, 2 and 3 are all met, sarcopenia is considered severe.

Inhospital diet is measured by patient record.

Eating habits are measured by patient survey.

Demographics are measured by demographic data.

Neurological diseases are taken from the hospital record

Waist circumference is measured in cm.

Hip circumference is measured in cm.

Obesitas is measured by body mass index.

Metamemory Questionnaire (MMQ) contentment scale is a participant-reported measure of memory satisfaction, ability, and strategy use..

Presurgical cognitive impairment is determined as cognitive performance of a test battery.