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Completed

NCT Number: NCT03814486

Retrospective Descriptive Study of Platelet Transfusion in Patients With Palliative Hematologic Malignancies at the University Hospital of Besançon

Development of palliative care is less effective for patients with hematologic malignancies. Limited data is available for end of life care in this population, moreover with thrombocytopenic patients. Thrombopenia is a frequent complication, specific of bone marrow involvement in those diseases or its treatments. Yet, a few studies was interested in, whereas platelet transfusion is the only treatment indicated. As it represent a scarce, limited resource, the ethical principles are in conflict in this setting.

The purpose of this study was to describe retrospectively platelet transfusion in the six last few month of life of patients with hematologic malignancies at the CHU of Besançon (France) between 01/07/15 and 31/12/16.

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Key information

Conditions

Platelet Transfusion Palliative Care

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Moracchini

Besançon, 25000, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient with hematological malignancies
  • transfused in platelet at least once in the last 6 months of life
  • hospitalised or follow up at the CHU of Besancon at least once
  • dead during the period of the study

Exclusion criteria

  • patient with other oncologic malignancies
  • not transfused in platelet in the last 6 months of life
  • never hospitalised or follow up at the CHU of Besancon
  • alive

Treatment and study plan

descriptive

Other

evaluate in number and efficacy platelet transfusion at the end of life, demographic characteristic are also noted

Primary outcomes

  1. evaluate frequency of platelet transfusion at the end of life

    Time frame: 18 months (between 07/01/2015 and 12/31/2016)

    to calculate the number of platelet transfusion at the end of life. The number of platelet transfusion between 6 months and death are collected in each periods of 2 weeks to calculate the number of transfusion per patient during each 2 weeks.

  2. evaluate efficacy of prophylactic platelet transfusion at the end of life

    Time frame: 18 months (between 07/01/2015 and 12/31/2016)

    to calculate the platelet yield in percentage

  3. evaluate efficacy of non prophylactic platelet transfusion at the end of life

    Time frame: 18 month (between 07/01/2015 and 12/31/2016)

    to calculate the transfusional interval between 2 platelet transfusion in days

Secondary outcomes

  1. demographic characteristic

    Time frame: 18 months (between 07/01/2015 and 12/31/2016)

    characteristic of patient (age, diagnosis,location of death, palliative care received...)

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Besancon

Other

Registry information

Official study title

Etude Descriptive Retrospective de la Transfusion Plaquettaire Chez Des Patients Atteints d'hémopathie Maligne en Phase Palliative et Suivis au CHU de Besançon

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jan 24, 2019
Registry last updated
Jan 30, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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