Retrospective Data Analysis of CKRT (Continuous Kidney Replacement Therapy) Treatments in Adult Mode With multiFiltratePRO

The multiFiltratePRO is a device for extracorporeal blood purification treatments.

In this retrospective analysis, the treatments of patients who received at least one treatment with the investigational device as mentioned between January 2015 and January 2024 will be documented in a chronological order. No further control treatments will be investigated in this one-arm design. The design is considered to be appropriate to reflect daily clinical practice and to contribute to empirical evidence of performance of the multiFiltratePRO system.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Failure Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Evangelisches Klinikum Bethel gGmbH Universitätsklinikum OWL der Universität Bielefeld, Bielefeld, North Rhine-Westphalia, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All patients with an indication for the extracorporeal blood treatment suffering from AKI who received CKRT adult mode treatment for at least once with: Heparin-Continuous veno-venous hemofiltration Hep-CVVH (Pre CVVH, Post CVVH and Pre-Post CVVH), Heparin-Continuous veno-venous hemodialysis Hep-CVVHD, Heparin-Continuous veno-venous hemodiafiltration Hep-CVVHDF (Pre-CVVHDF and Post-CVVHDF), Citrate-Calcium(Ci-Ca)-CVVHD, Citrate-Calcium(Ci-Ca) CVVHDF, between January 2015 and January 2024, with the investigational device, have to be included in the study in chronological order.
No age restriction for heparin modes
Age ≥ 18 years for Ci-Ca modes at treatment start
Patient´s body weight ≥ 40kg irrespective of age
Acute Kidney Injury (AKI) OR chronic dialysis patients with clinical indication for CKRT

Exclusion criteria

Participation in an interventional clinical study during the retrospectively collected CKRT treatment data
Previous participation in the same study
No study-specific exclusion criteria based on contraindications due to the retrospective character of the study

Treatment and study plan

multiFiltratePRO with all CKRT treatment modes

Other

Retrospective Data Analysis of CKRT treatments in adult mode with multiFiltratePRO

Primary outcomes

Analysis of treatments with multiFiltratePRO

Time frame: documentation of max.7 treatment days

Performance data of defined multiFiltratePRO CKRT treatments in adult mode with regard to fluid balance (effluent dose) are analysed

Sponsors and collaborators

Lead sponsor

Fresenius Medical Care Deutschland GmbH

Industry

Collaborators

Metronomia Clinical Research GMBH

Registry information

Official study title

Retrospective Data Analysis of CKRT Treatments in Adult Mode With multiFiltratePRO

Acronym: CKRT-AKI

Important dates

Study start: 2024
Primary completion: 2025
Study completion: 2025
First posted: Feb 1, 2024
Registry last updated: Jun 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed