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NCT Number: NCT07151664

Retrospective Analysis of Quality of Life Changes in Patients Undergoing Parathyroidectomy for End-Stage Renal Disease

The purpose of this study is to characterize changes in quality of life in patients who had undergone parathyroidectomy for secondary hyperparathyroidism due to end-stage renal disease, based on data extracted from an established database

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Key information

Conditions

Secondary Hyperparathyroidism Due to Renal Causes Chronic Disease Disease Attributes End Stage Renal Failure Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Data were retrospectively collected from an established database of patients who underwent surgery for renal secondary hyperparathyroidism (SHPT). Extracted information included demographic and clinical characteristics (age, gender, education level, clinical symptoms), baseline quality of life assessed by the 36-item Short-Form Health Survey (SF-36), and completed follow-up assessments of SF-36 scores, depression, and anxiety at one, three, six months, and one year postoperatively.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥18 years； Patients who had undergone parathyroidectomy for secondary hyperparathyroidism due to end-stage renal disease.

Exclusion criteria

Patients who underwent kidney transplantation during the study period. Patients with postoperative whole blood parathyroid hormone levels >300 pg/mL within the first week after surgery.

Patients with missing postoperative quality of life assessment data.

Treatment and study plan

Quality of life progression after parathyroidectomy

Other

Study the progression of quality of life

Primary outcomes

  1. Quality of life scores change with respect to time

    Time frame: up to 1 year

    Quality of life was assessed using the 36-item Short Form Health Survey (SF-36) scale. Completed responses for each of the 36 items were extracted from the database. Item responses were aggregated to calculate scores for each of the eight dimensions. Scores for each dimension range from 0 to 100, with higher scores indicating better health status

Secondary outcomes

  1. Anxiety and depression score change with respect to time

    Time frame: up to 1 year

    Anxiety and depression were evaluated using the Hospital Anxiety and Depression Scale (HADS). Completed responses for the 14-item HADS, comprising 7 items each for the anxiety (HADS-A) and depression (HADS-D) subscales, were extracted from the database. Item scores range from 0 to 3, and were summed to yield separate scores for anxiety and depression

  2. Bone pain scores change with respect to time

    Time frame: up to 1 year

    Bone pain was evaluated using the Numerical Rating Scale (NRS). Completed NRS scores, ranging from 0 to 10, were extracted from the database. In this scale, 0 represents no pain, 1-3 represents mild pain, 4-6 represents moderate pain, 7-9 represents severe pain, and 10 represents the worst pain

  3. Length of hospital stay

    Time frame: an average of 1 week

Study contacts

Contact information is provided by the study sponsor or research team.

Chunling Jiang, PhD

CONTACT

[email protected]

+862885423593

Sponsors and collaborators

Lead sponsor

West China Hospital

Other

Registry information

Official study title

Quality of Life Change in Patients Undergoing Parathyroidectomy With Secondary Hyperparathyroidism Due toEnd-stage Renal Failure: a Retrospective Cohort Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Sep 3, 2025
Registry last updated
Sep 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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