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NCT Number: NCT06042322

Retrospective Analysis of Pain After Nerve Block in Surgical Patients

This is a retrospective study looking at patients who received a nerve block for surgery and assessing pain after the nerve block resolves, with or without an educational intervention, over two periods of time.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Regional Anesthesia Morbidity Acute Pain Arthritis Joint Diseases Knee Osteoarthritis Musculoskeletal Diseases Neurologic Manifestations Osteoarthritis Osteoarthritis, Knee Pain Pathological Conditions, Signs and Symptoms Rheumatic Diseases Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

About this study

Regional anesthesia (RA) is a vital tool that can serve as the primary anesthetic or as part of a multimodal perioperative pain regimen. RA is strongly associated with decreased acute and persistent pain and opioid consumption postoperatively. However, some patients experience an acute worsening of pain into the severe range around the time of RA resolution, also known as "rebound pain" (RP). The incidence of RP has been reported as high as 40-50% after a single shot nerve block for patients undergoing ambulatory surgery.

This retrospective study aims to look at patients who received a nerve block for surgery and assessing pain after the nerve block resolves in the presence and absence of certain interventions, such as a multidisciplinary educational intervention.

The investigators will assess patients who received a primary total knee arthroplasty who received a single shot adductor canal nerve block, received pericapsular injection by the surgeon, and had a length of stay > 16 hours.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • primary total knee arthroplasty
  • received an adductor canal nerve block
  • received pericapsular injection by surgeon intraoperatively
  • admitted for overnight stay and > 16 hours post-nerve block

Exclusion criteria

  • age < 18
  • prior total knee arthroplasty on ipsilateral knee

Treatment and study plan

Educational Intervention

Other

Multidisciplinary educational intervention was performed by orthopedic, anesthesia, and nursing team. This included a discussion of the patient's pain plan and a patient visit.

Primary outcomes

  1. Difference in maximum pain score, 0-10; (0 = no pain, 10 = worst pain)

    Time frame: 6-24 hours

    Difference in maximum pain score, numerical pain rating scale 0-10, 6-24 hours after nerve block between the two cohorts

Secondary outcomes

  1. Average pain score 0-10; (0 = no pain, 10 = worst pain)

    Time frame: 6-24 hours

    Difference in area under the curve of pain scores, numerical pain rating scale 0-10, 6-24 hours after nerve block between the two cohorts (educational intervention and non-educational intervention time periods)

  2. Difference in incidence of rebound pain

    Time frame: 6-24 hours

    Difference in incidence pain score ≥ 7 between 6-24 hours post nerve block between the two cohorts

  3. Comparison of evening opioids given

    Time frame: 6-24 hours

    Comparison of if evening opioids were or were not given (yes/no) between the two cohorts

  4. Difference in total opioids given

    Time frame: 6-24 hours

    Difference in total opioids given (mEq of morphine) between the two cohorts

  5. Difference in length of stay

    Time frame: 0-2 years

    Difference in length of stay (days) between the two cohorts

Sponsors and collaborators

Lead sponsor

Brigham and Women's Hospital

Other

Registry information

Official study title

Retrospective Analysis of Pain in Patients Who Receive a Nerve Block for Surgery

Important dates

Study start
2017
Primary completion
2028
Study completion
2028
First posted
Sep 18, 2023
Registry last updated
Apr 28, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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