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NCT Number: NCT06851520

Retrospective Analysis of Different Quadratus Lumborum Block Techniques on Recovery Quality and Analgesic Consumption in Radical Cystectomy Patients

This retrospective observational study evaluates the effects of different Quadratus Lumborum Block (QLB) techniques on postoperative recovery and total opioid consumption in patients undergoing radical cystectomy under general anesthesia. The study will analyze intraoperative and postoperative patient records from October 15, 2023, to October 15, 2024, at Tekirdağ Namık Kemal University Hospital.

Patients who received anterior or posterior QLB for postoperative analgesia will be included. Data collection will involve demographic information, total opioid consumption (morphine milligram equivalents), recovery quality scores (QoR-15), postoperative pain scores (Visual Analog Scale, VAS), time to first rescue analgesic administration, frequency of rescue analgesic use, and incidence of postoperative nausea and vomiting (PONV).

The retrospective analysis will compare the two QLB techniques to determine if there is a significant difference in postoperative opioid consumption and recovery quality. Statistical methods will be used to assess pain scores over time, opioid consumption, and overall recovery quality.

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Key information

Conditions

Bladder Cancer Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Male Urogenital Diseases Neoplasms Neoplasms by Site Opioid Consumption Postoperative Pain Management Recovery Quality Urinary Bladder Diseases Urinary Bladder Neoplasms Urogenital Diseases Urogenital Neoplasms Urologic Diseases Urologic Neoplasms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tekirdağ Namık Kemal University Hospital

Tekirdağ, Turkey (Türkiye)

About this study

Postoperative pain management plays a crucial role in optimizing recovery after radical cystectomy, as inadequate pain control can lead to increased opioid consumption and delayed rehabilitation. This retrospective observational study examines the effects of two different Quadratus Lumborum Block (QLB) techniques-anterior and posterior approaches-on postoperative pain and opioid consumption.

The study includes patients who underwent radical cystectomy under general anesthesia at Tekirdağ Namık Kemal University Hospital between October 15, 2023, and October 15, 2024. The primary focus is to compare total opioid consumption (morphine milligram equivalents) within the first 24 hours after surgery between the two groups.

Secondary outcomes include:

  • Pain scores at multiple time points (0, 2, 6, 12, 24 hours), measured using the Visual Analog Scale (VAS)
  • Postoperative recovery quality scores (QoR-15)
  • Time to first rescue analgesic administration
  • Frequency of rescue analgesic use
  • Incidence of postoperative nausea and vomiting (PONV)

Data will be collected from intraoperative and postoperative patient records. Statistical analysis will compare anterior vs. posterior QLB techniques, evaluating differences in postoperative opioid consumption, pain relief efficacy, and recovery quality (QoR-15 scores).

This study aims to provide evidence-based insights into the use of regional anesthesia techniques for radical cystectomy patients, supporting the refinement of multimodal analgesia strategies to optimize pain management and minimize opioid exposure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent radical cystectomy under general anesthesia between October 15, 2023, and October 15, 2024.
  • Patients who received anterior or posterior quadratus lumborum block (QLB) for postoperative analgesia.
  • Age: 18-65 years.
  • ASA Physical Status Classification: I-III.
  • BMI < 35 kg/m².
  • Complete medical records available for retrospective review.

Exclusion criteria

  • Patients who received a different postoperative analgesia technique (e.g., epidural, TAP block).
  • Incomplete or missing medical records.
  • Psychiatric disorders that could affect pain perception and reporting.
  • Coagulopathy or bleeding disorders.
  • Hepatic or renal failure.
  • Chronic opioid use before surgery.
  • Patients who required unplanned conversion to open surgery.

Treatment and study plan

Anterior Quadratus Lumborum Block (QLB)

Procedure

A regional anesthesia technique where local anesthetic is injected anterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management.

posterior Quadratus Lumborum Block (QLB)

Procedure

A regional anesthesia technique where local anesthetic is injected posterior to the quadratus lumborum muscle under ultrasound guidance for postoperative pain management.

Primary outcomes

  1. Total Opioid Consumption (Morphine Milligram Equivalents) in the First 24 Hours

    Time frame: 0-24 hours postoperatively

    The total amount of opioids (converted to morphine milligram equivalents) administered postoperatively within the first 24 hours following radical cystectomy.

    Continuous variable (mg of morphine equivalent)

Secondary outcomes

  1. Pain Scores Using Visual Analog Scale (VAS) at Multiple Time Points

    Time frame: 0, 2, 6, 12, and 24 hours postoperatively

    Postoperative pain levels measured using the Visual Analog Scale (VAS) at predetermined time points: 0, 2, 6, 12, and 24 hours.

    Ordinal variable (0-10 VAS score, higher scores indicate more pain)

  2. Postoperative Recovery Quality (QoR-15 Score)

    Time frame: 24 hours postoperatively

    Recovery quality assessed using the QoR-15 questionnaire, a validated patient-reported outcome measure.

    Continuous variable (QoR-15 total score, higher scores indicate better recovery quality)

  3. Time to First Rescue Analgesic Administration

    Time frame: 0-24 hours postoperatively

    The duration (in minutes) from the end of surgery until the first administration of rescue analgesia.

    Continuous variable (minutes)

  4. Frequency of Rescue Analgesic Use

    Time frame: 0-24 hours postoperatively

    The number of times rescue analgesics were administered during the first 24 hours postoperatively.

    Count variable (number of doses)

  5. Incidence of Postoperative Nausea and Vomiting (PONV)

    Time frame: 0-24 hours postoperatively

    The proportion of patients who experience postoperative nausea and vomiting within the first 24 hours.

    Binary variable (Yes/No; presence of PONV)

Sponsors and collaborators

Lead sponsor

Namik Kemal University

Other

Registry information

Acronym: QLB-CYS

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Feb 28, 2025
Registry last updated
Feb 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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