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NCT Number: NCT05181696

Retrospective Analysis of Chest X-ray Severity Scoring System of COVID-19 Pneumonia

The research will be retrospective, and will include all patients who were admitted during 2020 and 2021 in the COVID-19 ICU of University Hospital Center Osijek due to pneumonia caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The association of chest x-ray infiltrate evolution with changes in laboratory inflammatory parameters and respiratory function parameters will be examined.

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Key information

About this study

The research will be retrospective, and will include a review of medical history of all patients admitted in the COVID-19 ICU of the University hospital Osijek during 2020 and 2021. Associated comorbidity, hospital admission date, intubation date, mechanical ventilation, extubation, discharge, and patient final outcome will be recorded for each patient. By analyzing X-rays of the lungs by radiology specialists, inflammatory infiltrates in the lungs will be quantified via the Brixia system, during hospital admission, admission to the Respiratory Center, and during treatment at the Respiratory Center. All patients will have their Sequential Organ Failure Assessment (SOFA) and/or Acute Physiology and Chronic Health Evaluation (APACHE II) values calculated upon admission. Inflammatory parameters (c-reactive protein (CRP), procalcitonin (PCT), interleukine-6 (IL-6), ferritin), red blood cell count, leukocytes, blood urea nitrogen (BUN), arterial blood gases and ventilation parameters on admission to the hospital, admission to the ICU, and on several occasions during treatment in the ICU will be analysed. Also, empirical use of antibiotics, the occurrence of bacterial superinfections, sepsis and organic failure will be noted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pneumonia caused by SARS-CoV-2 virus
  • Admission to the ICU COVID-19 unit

Exclusion criteria

  • Patients with lung tumors or history of lung resection

Treatment and study plan

Chest X-Ray

Diagnostic Test

Retrospective analysis of chest x-rays of patients with COVID-19

Primary outcomes

  1. Chest x-ray severity score

    Time frame: 21 days

    The influence of the dynamics of radiographic changes quantified by Brixia score on the outcome of COVID-19 patients will be examined

  2. Inflammatory markers

    Time frame: 21 days

    The influence of serum levels of inflammatory parameters, and clinical and laboratory indicators of organic failure on chest x-ray severity score will be examined

Study contacts

Contact information is provided by the study sponsor or research team.

Ivana Haršanji Drenjančević, PhD

CONTACT

[email protected]

+385915108941

Nenad Nešković, PhD

CONTACT

[email protected]

+395996787250

Sponsors and collaborators

Lead sponsor

Osijek University Hospital

Other

Registry information

Official study title

Radiographic Severity Scoring System and Clinical and Laboratory Evolution of COVID-19 Pneumonia

Acronym: RANCH-COVID

Important dates

Study start
2020
Primary completion
2025
Study completion
2025
First posted
Jan 6, 2022
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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