Retrobulbar Block Versus Ketamine Infusion for Post-enucleation Analgesia

This study compares the efficacy and safety of two techniques, retrobulbar block versus intra-operative ketamine infusion, for control of post-operative pain occurring in patients undergoing ocular enucleation or evisceration performed under general anesthesia.

Completed

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Key information

Conditions

Enucleated; Eye Agnosia Evisceration; Operation Wound Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Perceptual Disorders Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kasr Al-Ainy Hospital, Cairo University

Cairo, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Ocular enucleation candidate patients
Ocular evisceration candidate patients

Exclusion criteria

Any condition contra-indicating general or local anesthesia
Allergy to any of the drugs used during the procedure

Treatment and study plan

Retrobulbar block

Procedure

Patients will receive a single retrobulbar injection with 3-4ml of an equal mixture of Lidocaine 2% & Bupivacaine 0.5% + Hyaluronidase (10 IU/ml), after induction of general anesthesia.

Other names: Local analgesia

Ketamine

Procedure

Patients will receive a 0.5 mg/kg bolus followed by an infusion of 0.25 mg/kg/h of intravenous Ketamine, after induction of general anesthesia.

Other names: IV analgesia

Primary outcomes

Time to the first post-operative rescue analgesia.

Time frame: 24 hours

Time (measured in minutes) elapsed till the patient requires to receive his first post-operative rescue analgesic dose.

Sponsors and collaborators

Lead sponsor

Nazmy Edward Seif

Other

Registry information

Official study title

Retrobulbar Block Versus Ketamine Infusion as Adjuvants to General Anesthesia for Post-operative Pain Control After Enucleation

Important dates

Study start: 2018
Primary completion: 2020
Study completion: 2020
First posted: Apr 25, 2018
Registry last updated: Jul 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed