Retinol-induced Dermatitis in Aged Skin

Topical therapy with retinoids is the only proven medical therapy for aged/photoaged human skin. However, topical therapy with retinoids often result in unwanted cutaneous dermatitis, including erythema and scaling. The reseachers intend to investigate the dose, frequency of use, and time dependence of topical retinol-induced dermatitis. The researchers intend to evaluate retinoid-induced dermatitis biochemically, including retinol regulation of retinoid responsive genes that control retinoid metabolism and serve as markers for retinoid bioactivity. The researchers will also investigate the role of EGF receptor pathway in retinoid-induced dermatitis.

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Key information

Conditions

Aged Skin Photoaged Skin

Age range

21 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Michigan Medical Center

Ann Arbor, Michigan, 48109, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Male or female
Subject is at least 21 years of age
Good general health
No disease states, physical conditions or medications that would impair evaluation of the test sites
Willingness and ability to follow protocol
Signed written and witnessed informed consent form
No use of oral retnoids in the past year
No use of topical steroids to the treatment area in the past 2 weeks

Exclusion criteria

Has received an experimental drug or used and experimental device in the 14 days prior to admission to the study
History of keloids
History of hypersensitivity to lidocaine or epinephrine
Pregnant or nursing women
Disease states or physical condition that would impair evaluation of the test sites or compliance with the protocol
History of chemical peels or laser treatments to the sites evaluated

Treatment and study plan

Primary outcomes

Retinoid-induced dermatitis

Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Official study title

Molecular Analyses of Retinoid-induced Dermatitis in Aged/Photoaged Human Skin

Important dates

Study start: 2009
Primary completion: 2014
Study completion: 2014
First posted: Mar 6, 2009
Registry last updated: Mar 13, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed