Retinal Pigment Epithelial Characteristics in Eyes With Neovascular Age-related Macular Degeneration Following Long-term Treatment With Anti Neovascular Endothelial Growth Factor

Purpose:

To assess retinal pigment epithelial (RPE) and retinal structural changes in eyes with neovascular age-related macular degeneration (AMD) treated with anti-vascular endothelial growth factor (anti-VEGF) during long-term follow-up and to evaluate morphological markers potentially influencing prognosis.

Methods:

18 patients (18 eyes) with neovascular AMD were recruited subsequent to completion the Avastin Versus Lucentis in Age Related Macular Degeneration (MANTA) study following a mean period of 84 months (range: 69-93 months). After receiving a loading dose of 3 intravitreal anti-VEGF injections subsequent to baseline of the MANTA study, patients were treated as-needed [pro re nata (PRN)]. Functional and morphological changes were assessed using spectral domain optical coherence tomography (SD-OCT).

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Key information

Conditions

Neovascular Age-related Macular Degeneration

Age range

66 year–98 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Inclusion and exclusion criteria corresponded to the criteria of the MANTA study

Exclusion criteria

Inclusion and exclusion criteria corresponded to the criteria of the MANTA study

Treatment and study plan

OCT

Device

Patients were recruited, visual acuity and optical coherence tomography Pictures were taken

Primary outcomes

visual acuity

Time frame: 93 months

visual acuity testing was performed

Sponsors and collaborators

Lead sponsor

Hospital Hietzing

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2016
Study completion: 2017
First posted: Sep 20, 2018
Registry last updated: Sep 20, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed