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NCT Number: NCT01928212

Retinal Nerve Fiber Layer Thickness Changes in Parkinson Disease: A Meta-analysis

Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness. A reduction of the RNFL thickness has been detected in several neurodegenerative diseases, such as multiple sclerosis, CADASIL and Alzheimer's disease. Different studies have reported RNFL changes also in Parkinson's disease (PD),a common neurodegenerative disease characterized by motor dysfunctions, originally described by James Parkinson in 1817. PD is characterized by selective dopaminergic neuronal cells loss, which may correlate with RNFL thinning. Previous studies on this subject, however, reported contradicting results. Some investigations reported reductions of the RNFL thickness while others did not. In the present study, in order to determine whether RNFL thickness is reduced in PD patients, we performed a meta-analysis and systematically evaluated RNFL thickness measurements with OCT in a series of PD patients and in the healthy control groups.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Wenzhou Medical College

Wenzhou, Zhejiang, 325000, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • case-control studies;
  • patients with PD were compared with healthy controls;
  • all subjects underwent RNFL thickness measurement by OCT;
  • studies should provide the data of peripapillary RNFL thickness;
  • sample size ≥10 in each group.

Exclusion criteria

  • authors did not make RNFL measurements;
  • study without healthy control group;
  • the outcome values can not be used for meta-analysis;
  • duplicated articles.

Treatment and study plan

optical coherence tomography

Device

Primary outcomes

  1. Retinal Nerve Fiber Layer Thickness

    Time frame: Baseline

    Retinal nerve fiber layer thickness included average thickness (360° measurement), temporal quadrant thickness (316-45°), superior quadrant thickness (46-135°), nasal quadrant thickness (136-225°) and inferior quadrant thickness (226-315°)was measured by OCT.

Sponsors and collaborators

Lead sponsor

Yifan Feng

Other

Collaborators

  • Wenzhou Medical University

Registry information

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Aug 23, 2013
Registry last updated
Jul 18, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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