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OpenTrials
Completed

NCT Number: NCT04118205

REtinaL Imaging & Ambulatory BLood PrEssure

High blood pressure is a common condition which generally does not have any symptoms. Its estimated that around one third of people with high blood pressure do not know they have it. The back of the eye called the retina is one of the few places in the human body allowing easy observation of blood vessels. This study aims to see if simple non-invasive imaging of the blood vessels of the retina will highlight people with high blood pressure.

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Key information

Conditions

Hypertension Blood Pressure Cardiovascular Diseases Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Clinical Research Centre, Western General Hospital

Edinburgh, City Of Edinburgh, EH4 2XU, United Kingdom

About this study

This will be a prospective, single centre study recruiting patients who are attending the ambulatory blood pressure clinic at the Western General Hospital. Suitable patients will be approached, and if they consent will have pictures of the back of each of their eyes taken. These pictures will then be reviewed, with certain measurements taken of the small blood vessels which can been seen at the back of the eye. These measurements will then be compared to the participants blood pressure readings to see if they might accurately correlate to blood pressure.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Attending ambulatory blood pressure clinic
  • Able to undertake ambulatory BP measurement
  • Able to undertake single clinic-based BP measurement
  • Able to undergo UWF retinal imaging with a SLO
  • Aged 18 to 90
  • Able to give informed consent

Exclusion criteria

  • People with known history of retinal surgery
  • People under the age of 18 years.
  • People that cannot: manoeuvre themselves to the SLO unaided, sit upright in a chair or wheelchair or position themselves comfortably for imaging.
  • People with epilepsy

Treatment and study plan

Primary outcomes

  1. Does retinal arteriovenous ratio correlate to systolic blood pressure

    Time frame: 1 day

    Retinal arteriovenous ratio (as measured by ultra-wide field imaging) will be correlated to mean daytime systolic blood pressure (as measured by 24-hour ambulatory blood pressure monitoring)

Secondary outcomes

  1. Does retinal arteriovenous ratio correlate to clinic systolic blood pressure

    Time frame: 1 day

    Retinal arteriovenous ratio (as measured by ultra-wide field imaging) will be correlated to clinic systolic blood pressure.

Sponsors and collaborators

Lead sponsor

University of Edinburgh

Other

Collaborators

  • NHS Lothian
  • Optos, PLC

Registry information

Official study title

REtinaL Imaging & Ambulatory BLood PrEssure: Validating Ultra-widefield Retinal Imaging Derived Biomarkers Against Ambulatory Blood Pressure

Acronym: RELIABLE

Important dates

Study start
2019
Primary completion
2019
Study completion
2021
First posted
Oct 8, 2019
Registry last updated
Mar 14, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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