Liang xiaoling
Guangzhou, Guangdong, 510000, China
Completed
NCT Number: NCT04491500
Retinal and Choroidal Circulation Changes Following Rapid Ascent to a High Altitude Environment
This is a prospective observational study. The purpose is to explore the effect of high altitude hypobaric hypoxia on retinal microcirculation and the change of the thickness of the retina and choroid by optical coherence tomography angiography (OCTA).
Completed
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Notify MeKey information
Conditions
Age range
18 year–70 year
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
Yushu is in Qinghai-Tibet plateau, an average altitude of 4000 m. The medical staff is limited in Yushu. Zhongshan ophthalmic center, sun yat-sen university in Yushu blindness project has lasted many years. Some medical staff who arrived at Yushu will have a plateau response. The high altitude hypoxia on retinal microcirculation evaluated by OCTA has not been reported. The aim of the study is to observe the microcirculation changes after exploring a hypobaric and hypoxia environment using OCTA, and relation with the plateau response. OCTA is a non-invasive examination and could see the microcirculation of the fundus directly and quickly.
Who can participate
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- The subjects who plan to go to Yushu within one month.
- Did not live on the high altitude of more than 1000 meters within 6 months.
Exclusion criteria
- Unable and unwilling to provide informed consent.
- Any ocular disease may influence the retinal and choroidal circulation.
Treatment and study plan
High attitude environment
BehavioralThe participants will go to 4000m altitude to work for two weeks.
Primary outcomes
-
retinal microcirculation changes
Time frame: 1 month
the vascular density measured by OCTA
Secondary outcomes
-
Retinal thickness changes
Time frame: 1 month
the retinal thickness measured by OCTA
-
Choroidal thickness changes
Time frame: 1 month
the subfoveal choroidal thickness measured by OCTA
-
The correlation of retinal microcirculation with the altitude illness
Time frame: 1 month
The relationship between retinal vascular density as measured by OCTA and the degree of altitude illness as measured by acute mountain sickness (AMS) scoring system
-
The changes of intraocular pressure
Time frame: 1 month
The changes of intraocular pressure measured by icare Tonometer
-
The changes of blood pressure including systolic and diastolic Blood Pressure
Time frame: 1 month
The changes of blood pressure measured by Blood Pressure Meter
-
The changes of blood oxygen
Time frame: 1 month
The changes of blood Oxygen measured by Pulse Oximeter
-
the degree of altitude illness
Time frame: 1 month
the degree of altitude illness was assessed by acute mountain sickness (AMS) scoring system
Sponsors and collaborators
Lead sponsor
Zhongshan Ophthalmic Center, Sun Yat-sen University
Other
Registry information
Official study title
Retinal and Choroidal Circulation Changes Following Rapid Ascent to a High Altitude Environment Evaluated by OCT Angiography
Important dates
- Study start
- 2020
- Primary completion
- 2020
- Study completion
- 2020
- First posted
- Jul 29, 2020
- Registry last updated
- Sep 16, 2020
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.