Resveratrol-enriched Grape Extract (Stilvid) in Primary and Secondary Prevention of Cardiovascular Disease

Inclusion criteria

FOR PRIMARY PREVENTION:

• Lack of known cardiovascular disease (coronary acute syndrome, stable ischemic cardiopathy, peripheric arteriopathy and cerebrovascular diseases).
• Age between 18 and 80 years.
• The above criteria and diabetes mellitus or at least two of the following risk factors:

• Active smoking (10 cigarettes or more per day).
• Arterial hypertension (>= 140/90 mmHg).
• Hypercholesterolemia (LDL-cholesterol >130 mg/dL and/or HDL-cholesterol < 45 mg/dL in women and 50 mg/dL in men).
• Obesity (BMI > 30 kg/m2)

FOR SECONDARY PREVENTION:

• Stable patients who coronary syndrome, cerebrovascular accident or peripheric arteriopathy event occurred at least 6 months or more before the recruitment in the study. In addition:

• Age between 18 and 80 years.
• Ejection fraction of left ventricle >=45%.
• Functional status I or II according to the New York Heart Association.
• Clinic stability in the recruitment (no symptoms of thoracic pain during the last month).
• Lack of residual lesions without vascularization in those patients with catheterism.

Exclusion criteria

FOR PRIMARY AND SECONDARY PREVENTION:

• Patients who do not satisfy inclusion criteria and:

• Known allergy to grapes
• Pregnancy or lactation
• Intake of nutraceuticals