Skip to main content
OpenTrials
Recruiting

NCT Number: NCT04451278

RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy

Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks. The analysis of r-fMRI can be done thanks to the graph theory, which is based on the based on the calculation of quantifiable parameters applied to the functional network studied, making it possible to assess its effectiveness.

To the knowledge of the investigators, no study has used graph theory applied to r-fMRI data in order to obtain parameters useful for the useful parameters for the individual prognosis of children who have to be operation for drug-resistant lesional epilepsy.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Epilepsy Brain Diseases Central Nervous System Diseases Nervous System Diseases

Age range

6 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation A De Rothschild

Paris, PARIS, 75019, France

Location status: Recruiting

Location contact

Amelie YAVCHITZ

CONTACT

[email protected]

0148036431

Sidney KRYSTAL

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient aged between 6 and 18 years
  • Receiving an MRI for lesional drug-resistant epilepsy
  • Affiliated or beneficiary of a social security plan
  • Whose parents or guardians have received information about the study and have given their express consent to participate in the study

Exclusion criteria

  • Contraindication to absolute or relative MRI (in particular, pregnant or breastfeeding women)
  • History of intracranial surgery
  • MRI performed under general anesthesia

Treatment and study plan

Primary outcomes

  1. Determine the prognostic value of topological parameters measured on local r-fMRI on the surgical success at one year of patients operated for drug-resistant epilepsy.

    Time frame: One year

    The variables measured with functional MRI will correspond to topological parameters of functional connectivity measured locally at the level of the lesion: the degree, the clustering coefficient and path length. Surgical success will be evaluated by a score of 1 on the modified Engel classification at one year after surgery.

Study contacts

Contact information is provided by the study sponsor or research team.

Amelie YAVCHITZ

CONTACT

[email protected]

01 48 03 65 65 ext. + 33

Sidney KRYSTAL

CONTACT

[email protected]

01 48 03 65 65 ext. + 33

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Acronym: RESPIRE

Important dates

Study start
2020
Primary completion
2027
Study completion
2028
First posted
Jun 30, 2020
Registry last updated
Jan 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.