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Recruiting

NCT Number: NCT06967441

Respiratory Virus Infections in Acute Heart Failure

Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort.

The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.

Recruiting

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Key information

Conditions

Acute Heart Failure Syndrome

Age range

19 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea

Loading trial locations.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult aged 19 years or older admitted to the cardiology department with acute heart failure
  • NT-proBNP >300 pg/mL
  • Clinician judgement of possible respiratory viral infection (fever >38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP >5 mg/dL)
  • Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons

Exclusion criteria

  • Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP >180mmHg or DBP >110mmHg), haemoglobin <7g/dL or AHF precipitated by medication non-adherence)
  • If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
  • If there is a clear other source of infection that can explain the fever

Treatment and study plan

Primary outcomes

  1. Respiratory virus PCR detection rate

    Time frame: Within 3 days of admission

    Respiratory virus PCR detection rate (especially RSV, influenza virus) in acute HF

Secondary outcomes

  1. Days of hospitalization

    Time frame: From admission to discharge during index hospitalization (upto 30 days)

    Days of hospitalization

  2. Rate of ICU care or ventilation

    Time frame: From admission to discharge during index hospitalization (upto 30 days)

    Rate of ICU care or ventilation

  3. In hospital mortality

    Time frame: From admission to discharge during index hospitalization (upto 30 days)

    In hospital mortality

  4. mortality

    Time frame: 12 month

    after discharge, 12-month mortality

  5. Rehospitalization

    Time frame: 12month

    after discharge, 12-month rehospitalization

Study contacts

Contact information is provided by the study sponsor or research team.

Minjae Yoon, MD

CONTACT

[email protected]

+82-10-6334-1917

Sponsors and collaborators

Lead sponsor

Minjae Yoon

Other

Collaborators

  • Samsung Medical Center
  • Seoul St. Mary's Hospital

Registry information

Official study title

Respiratory Virus Infections in Hospitalized Patients With Acute Heart Failure Syndrome: A Prospective Multi-center Observational Study

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
May 13, 2025
Registry last updated
Mar 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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